Advertisement

Primates

, Volume 24, Issue 2, pp 260–265 | Cite as

Effects of stimulation of hypothalamic “feeding areas” on endocrines and metabolism in normal and diabetic monkeys

  • S. K. Garg
  • G. S. Chhina
  • Baldev Singh
Article
  • 21 Downloads

Abstract

Electrical stimulation of hypothalamic “feeding areas” (VMH & LHA) through stereotaxically implanted electrodes was carried out in normal and streptozotocinized diabetic conscious male rhesus monkeys. In normal monkeys, the VMH stimulation resulted in a significant decrease in serum insulin and blood glucose while opposite responses were observed following LHA stimulation. Serum growth hormone, FFA and plasma cortisol levels increased significantly on stimulation of LHA and VMH in normal animals. The pattern of blood glucose and serum growth hormone responses to stimulation of “feeding areas” was similar in normal and diabetic animals. The serum insulin, FFA and plasma cortisol were largely unaffected while growth hormone increased significantly by stimulation of these areas in diabetes. The present study indicates that the stimulation of “feeding areas” does not alter the diabetic syndrome significantly nor does diabetes prevent the changes in metabolism seen after stimulation of “feeding areas.”

Keywords

Blood Glucose Growth Hormone Cortisol Level Rhesus Monkey Serum Insulin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Anand, B. K., 1955. A method of permanent implantation of electrodes in the central nervous system for stimulation and recording of action potentials in conscious animals.Ind. J. Physiol. & Allied Sci., 9: 1–6.Google Scholar
  2. Chhina, G. S. &J. S. Bajaj, 1972. Nervous regulation of glucose homeostasis. In:Insulin and Metabolism,J. S. Bajaj (ed.), Diabetic Association of India, Bombay, pp. 155–191.Google Scholar
  3. Frohman, L. A., 1971. The hypothalamus and metabolic control. In:Pathobiology Annual,H. L. Ioachim (ed.), Appleton-Century-Crofts, New York, pp. 353–372.Google Scholar
  4. ————,L. L. Bernardis &K. J. Kant, 1968. Hypothalamic stimulation of GH secretion.Science, 162: 580–582.PubMedGoogle Scholar
  5. ————, ———— &M. E. Stachura, 1974. Factors modifying plasma insulin and glucose responses to ventromedial hypothalamic stimulation.Metabolism, 23: 1047–1056.Google Scholar
  6. Goldman, J. K., J. D. Schnatz, L. L. Bernardis &L. A. Frohman, 1970. Adipose tissue metabolism of weanling rats after destruction of ventromedial hypothalamic nuclei: effects of hypophysectomy and growth hormone.Metabolism, 19: 995–1005.CrossRefPubMedGoogle Scholar
  7. ————, ————, ———— & ————, 1972. Effects of ventromedial hypothalamic destruction in rats with preexisting streptozotocin (SZT)-induced diabetes.Metabolism, 21: 132–136.CrossRefPubMedGoogle Scholar
  8. Herbert, V., K. Lau, C. W. Gottlieb &S. J. Bleicher, 1965. Coated charcoal immunoassay of insulin.J. Clin. Endocrinol. Metab., 25: 1375–1384.PubMedGoogle Scholar
  9. Hill, D. E., S. Mayes, D. DiBattista, R. Lockhart-Ewart &J. M. Martin, 1977. Hypothalamic regulation of insulin release in rhesus monkeys.Diabetes, 26: 726–731.PubMedGoogle Scholar
  10. Himsworth, R. L., P. W. Larmel &A. G. Frantz, 1972. The location of the chemo-receptor controlling GH secretion during hypoglycaemia in primates (rhesus monkeys).Endocrinology, 91: 217–226.PubMedGoogle Scholar
  11. Martin, J. M., W. Konijnendijk &P. R. Bouman, 1974. Insulin and growth hormone secretion in rats with ventromedial hypothalamic lesions maintained on restricted food intake.Diabetes, 23: 203–208.PubMedGoogle Scholar
  12. ————,C. C. Mok, J. Penfold, N. J. Howard &D. Crowne, 1973. Hypothalamic stimulation of insulin release.J. Endocrinol., 58: 681–682.PubMedGoogle Scholar
  13. Mattingly, D., 1962. A simple fluorimetric method for the estimation of free 11-hydroxy-corticoids in human plasma.J. Clin. Path., 15: 374–379.PubMedGoogle Scholar
  14. Novak, M., 1965. Colorimetric ultramicro method for the determination of free fatty acids.J. lipid Res., 6: 431–433.PubMedGoogle Scholar
  15. Sharma, N. C. &B. K. Sur, 1966. Improved method for estimating blood sugar.J. Clin. Path., 19: 630–631.PubMedGoogle Scholar
  16. Shimazu, T., 1967. Glycogen synthetase activity in liver: regulation by autonomic nerves.Science, 156: 1256–1257.PubMedGoogle Scholar
  17. Smith, G. P. &A. W. Root, 1971. Dissociation of changes in growth hormone and adrenocortical hormone levels during brain stimulation of monkeys.Neuroendocrinology, 8: 235–244.PubMedGoogle Scholar
  18. Snider, R. S. &J. L. Lee, 1961.A Stereotaxic Atlas of the Monkey Brain (Macaca mulatta). Univ. of Chicago Press, Chicago.Google Scholar

Copyright information

© Japan Monkey Centre 1983

Authors and Affiliations

  • S. K. Garg
    • 1
  • G. S. Chhina
    • 1
  • Baldev Singh
    • 1
  1. 1.Department of BiologyGuru Nanak Dev UniversityAmritsarIndia

Personalised recommendations