Summary
IntactAnaplasma marginale, Babesia bigemina andBabesia argentina carrier calves treated intramuscularly five or ten times with 2·5 mg/kg of imidocarb dihydrochloride at 48 hour intervals, eliminated theBabesia infections but notAnaplasma infections. The parasitaemias became microscopically undemonstrable within 4 days following the first treatment and the packed cell volumes increased significantly within 18 days. Intoxications resulting in fatalities occurred in five of six calves given 10 intramuscular treatments of 2·5 mg/kg of imidocarb dihydrochloride at 48 hour intervals.
Résumé
Des veaux porteurs sains d'Anaplasma marginale, Babesia bigemina etBabesia argentina, traités à 5 ou 10 reprises, en intramusculaire avec 2,5 mg/kg de ce corps, à 48 heures d'intervalle, éliminent les Babésies mais non les Anaplasmes. Les parasitémies deviennent microscopiquement nuisibles dans les quatre jours qui suivent la première injection et avec accroissement significatif, dans les dix huit jours, des éléments cellulaires sanguins. Des accidents mortels ont été observés sur cinq à six veaux, à la suite de traitements comportant dix injections intramusculaires de 2,5 mg/kg d'Imidocarb dihydrochloride à 48 heures d'intervalle.
Sumario
Terneros enteros portadores deAnaplasma marginale, Babesia bigemina y Babesia argentina tratados intramuscularmente cinco ó diez veces con 2·5 mg/kg de imidocarb dihydrochloride con 48 horas de intervalo, eliminaron las infecciones conBabesia pero no las deAnaplasma. Las parasitemias se tornaron indemostrables microscopicamente dentro de los primeros cuatro dias de iniciado el tratamiento, y los volúmenes de hematocrito incrementaron significativamente dentro de 18 dias. Intoxicaciones que resultaron en perdidas occurrieron en cinco de seis terneros sometidos a diez tratamientos intramusculares de 2·5 mg/kg de imidocarb dihydrochloride con 48 horas de intervalo.
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References
Anonymous (1958).A Manual for Conducting the Complement Fixation Test for Anaplasmosis. Agriculture Research Service, United States Department of Agriculture, Washington, DC.
Beveridge, Elizabeth (1969). Babesicidal effect of basically substituted carbinilides. II. Imidocarb in rats and mice: toxicity and activity againstBabesia rodhaini.Research in Veterinary Science,10, 534–539.
Brown, C. G. B. &Berger, J. (1970). Chemotherapy of experimentalBabesia bigemina infections with imidocarb dihydrochloride.Tropical Animal Health and Production,2, 196–203.
Callow, L. L. &McGregor, W. (1970). The effect of imidocarb againstBabesia argentina andBabesia bigemina infections of cattle.Australian Veterinary Journal,46, 195–200.
Hart, C. B., Roy-Smith, F., Berger, J., Simpson, Ruth M. & McHardy, N. (1971). Imidocarb for control of babesiosis and anaplasmosis.Proceedings XIX World Veterinary Congress, Mexico City, Mexico, p. 616.
Hidalgo, R. J. &Dimopoullos, G. T. (1967). Complement-fixation microprocedures for anaplasmosis.American Journal of Veterinary Research,28, 245–251.
Kuttler, K. L. (1971). Promising therapeutic agents for the elimination ofAnaplasma marginale in the carrier animal. InProceedings of the Seventy-fifth Meeting of the United States Animal Health Association, pp. 924–98.
Mahoney, D. F. (1962). Bovine babesiosis: diagnosis of infection by a complement-fixation test.Australian Veterinary Journal,38, 48–52.
Mahoney, D. F. (1967). Bovine babesiosis: preparation and assessment of complement fixing antigens.Experimental Parasitology,20, 232–241.
Mahoney, D. F. &Saal, J. R. (1961). Bovine babesiosis: thick blood films for the detection of parasitaemia.Australian Veterinary Journal,37 44–47.
Roby, T. O. (1972). The inhibitory effect of imidocarb on experimental anaplasmosis in splenectomized calves.Research in Veterinary Science,13, 519–522.
Roby, T. O. &Mazzola, V. (1972). Elimination of the carrier state of bovine anaplamosis with imidocarb.American Journal of Veterinary Research,33, 1931–1933.
Roy-Smith, F. (1971). The prophylactic effects of imidocarb againstBabesia argentina andBabesia bigemina infections of cattle.Australian Veterinary Journal,47, 418–420.
Schmidt, Gisela, Hirt, R. &Fischer, R. (1969). Babesicidal effect of basically substituted carbanilides. I. Activity againstBabesia rodhaini in mice.Research in Veterinary Science,10, 530–533.
Wood, J. C. (1971). The activity of imidocarb againstBabesia infections of cattle.Irish Veterinary Journal,25, 254–257.
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Adams, L.G., Todorovic, R.A. The chemotherapeutic efficacy of imidocarb dihydrochloride on concurrent bovine anaplasmosis and babesiosis. Trop Anim Health Prod 6, 79–84 (1974). https://doi.org/10.1007/BF02380542
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DOI: https://doi.org/10.1007/BF02380542