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The chemotherapeutic efficacy of imidocarb dihydrochloride on concurrent bovine anaplasmosis and babesiosis

II. The effects of multiple treatments

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Summary

IntactAnaplasma marginale, Babesia bigemina andBabesia argentina carrier calves treated intramuscularly five or ten times with 2·5 mg/kg of imidocarb dihydrochloride at 48 hour intervals, eliminated theBabesia infections but notAnaplasma infections. The parasitaemias became microscopically undemonstrable within 4 days following the first treatment and the packed cell volumes increased significantly within 18 days. Intoxications resulting in fatalities occurred in five of six calves given 10 intramuscular treatments of 2·5 mg/kg of imidocarb dihydrochloride at 48 hour intervals.

Résumé

Des veaux porteurs sains d'Anaplasma marginale, Babesia bigemina etBabesia argentina, traités à 5 ou 10 reprises, en intramusculaire avec 2,5 mg/kg de ce corps, à 48 heures d'intervalle, éliminent les Babésies mais non les Anaplasmes. Les parasitémies deviennent microscopiquement nuisibles dans les quatre jours qui suivent la première injection et avec accroissement significatif, dans les dix huit jours, des éléments cellulaires sanguins. Des accidents mortels ont été observés sur cinq à six veaux, à la suite de traitements comportant dix injections intramusculaires de 2,5 mg/kg d'Imidocarb dihydrochloride à 48 heures d'intervalle.

Sumario

Terneros enteros portadores deAnaplasma marginale, Babesia bigemina y Babesia argentina tratados intramuscularmente cinco ó diez veces con 2·5 mg/kg de imidocarb dihydrochloride con 48 horas de intervalo, eliminaron las infecciones conBabesia pero no las deAnaplasma. Las parasitemias se tornaron indemostrables microscopicamente dentro de los primeros cuatro dias de iniciado el tratamiento, y los volúmenes de hematocrito incrementaron significativamente dentro de 18 dias. Intoxicaciones que resultaron en perdidas occurrieron en cinco de seis terneros sometidos a diez tratamientos intramusculares de 2·5 mg/kg de imidocarb dihydrochloride con 48 horas de intervalo.

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Adams, L.G., Todorovic, R.A. The chemotherapeutic efficacy of imidocarb dihydrochloride on concurrent bovine anaplasmosis and babesiosis. Trop Anim Health Prod 6, 79–84 (1974). https://doi.org/10.1007/BF02380542

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  • DOI: https://doi.org/10.1007/BF02380542

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