Skip to main content
Log in

Imidocarb dipropionate therapy in Kenyan anaplasmosis and babesiosis

  • Published:
Tropical Animal Health and Production Aims and scope Submit manuscript

Summary

The ability of imidocarb dipropionate to cure and sterilise experimental syringe passaged infections of Kenyan strains ofAnaplasma marginale andBabesia bigemina in cattle was investigated. Splenectomised calves with rising parasitaemias ofB. bigemina were rapidly cured by the subcutaneous injection of imidocarb at 1 mg/kg and heifers were sterilised of low infections ofB. bigemina by doses of imidocarb down to 0·5 mg/kg.

Heifers with rising parasitaemias ofA. marginale were rapidly cured by the subcutaneous injection of 3 mg/kg of imidocarb dipropionate but two doses of 6 mg/kg imidocarb dipropionate, with a 2-week interval between doses, failed to sterilise the infections of heifers known to be carryingA. marginale.

Résumé

Le pouvoir curatif et stérilisant du dipropionate d'Imidocarbe dans les infections expérimentales par passages à la seringue des souches kényanes d'Anaplasma marginale etBabesia bigemina a été évalué. Des veaux splénectomisés en parasitémie ascendante àB. bigemina ont été rapidement guéris par injection sous-cutanée d'imidocarbe à 1 mg/kg et des génisses faiblement parasitées ont été débarrassées deB. bigemina par des doses d'imidocarbe jusqu'à 0,5 mg/kg.

Des génisses en parasitémie ascendante àA. marginale ont été rapidement guéries par l'injection sous-cutanée de 3 mg/kg de dipropionate d'imidocarbe, mais deux doses de 6 mg/kg administrées à deux semaines d'intervalle n'ont pas réussi à stériliser les infections des génisses connues comme porteuses d'A. marginale.

Sumario

La abilidad del imidocarb dipropionate de curar y esterilizar infecciones experimentales con cepas de Kenya deAnaplasma marginale yBabesia bigemina en bovinos ha sido investigada. Terneros esplenectomizados y con parasitemias elevadas deB. bigemina fueron rapidamente curados mediante la inyeccion subcutanea de imidocarb a 1 mg/kg, y terneras fueron esterilizadas de infecciones bajas deB. bigemina con dosis de imidocarb de 0,5 mg/kg. Terneras con parasitemias elevadas deA. marginale fueron rapidamente curadas por la inyeccion subcutanea de 3 mg/kg de imidocarb dipropionate pero dos dosis de 6 mg/kg, con dos semanas de intervalo entre las dosis fueron inefectivas en esterilizar las infecciones de las terneras conocidas portadoras deA. marginale.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Anon. (1958).A Manual for Conducting the Complement-fixation Test for Anaplasmosis. Agricultural Research Service, US Department of Agriculture.

  • Brown, C. G. D. &Berger, J. (1970). Chemotherapy of experimentalBabesia bigemina infections with imidocarb dihydrochloride.Tropical Animal Health and Production,2, 196–203.

    Article  Google Scholar 

  • Callow, L. L. &McGregor, W. (1970). The effect of imidocarb againstBabesia argentina andBabesia bigemina infections of cattle.Australian Veterinary Journal,46, 195–200.

    CAS  PubMed  Google Scholar 

  • Hart, C. B., Roy-Smith, F., Berger, J., Simpson, R. M. & McHardy, N. (1971). Imidocarb for control of babesiosis and anaplasmosis.Proceedings of the XIX World Veterinary Congress, Mexico City, Mexico,2, 616.

  • Kuttler, K. L. (1972). Combined treatment with a dithiosemicarbazone and oxytetracycline to eliminateAnaplasma marginale infections in splenectomised calves.Research in Veterinary Science,13, 536–539.

    CAS  PubMed  Google Scholar 

  • McHardy, N. (1974). The effects of injecting anti-erythrocyte serum into calves infected withAnaplasma marginale.Annals of Tropical Medicine and Parasitology,68, 51–57.

    CAS  PubMed  Google Scholar 

  • McHardy, N. &Simpson, R. M. (1973). Attempts at immunizing cattle against anaplasmosis using a killed vaccine.Tropical Animal Health and Production,5, 166–173.

    Article  CAS  PubMed  Google Scholar 

  • Ristic, M. (1962). A capillary tube-agglutination test for anaplasmosis—a preliminary report.Journal of the American Veterinary Medical Association,141, 588–594.

    CAS  PubMed  Google Scholar 

  • Ristic, M. (1968). Anaplasmosis. InInfectious Blood Diseases of Man and Animals, Chapter 23 (eds. D. Weinman & M. Ristic). Academic Press Inc., NY.

    Google Scholar 

  • Roby, T. O. (1971). Une neuva droga experimental para el tratamiento de la anaplasmosis y la babesiosis.Proc. v. Congreso Latinoamericano de Microbiologia,07, 92.

    Google Scholar 

  • Roby, T. O. (1972). The inhibitory effect of imidocarb on experimental anaplasmosis in splenectomised calves.Research in Veterinary Science,13, 519–522.

    CAS  PubMed  Google Scholar 

  • Roby, T. O. &Mazzola, V. (1972). Elimination of the carrier state of bovine anaplasmosis with imidocarb.American Journal of Veterinary Research,33, 1931–1933.

    CAS  PubMed  Google Scholar 

  • Wood, J. C. (1971). The activity of imidocarb againstBabesia infections of cattle.Irish Veterinary Journal,25, 254–257.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

McHardy, N., Simpson, R.M. Imidocarb dipropionate therapy in Kenyan anaplasmosis and babesiosis. Trop Anim Health Prod 6, 63–70 (1974). https://doi.org/10.1007/BF02380540

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02380540

Keywords

Navigation