Skip to main content

Advertisement

SpringerLink
Log in

Effects and regulation of prostaglandins in bone: Possible implications for the pathogenesis of osteoporosis

  • 5. Prostaglandins In Bone Metabolism
  • Published:
Journal of Bone and Mineral Metabolism Aims and scope Submit manuscript

Abstract

Prostaglandins (PG's) are complex regulators of bone metabolism which have biphasic effects on both bone formation and resorption. PG's, particularly PGE2, are produced abundantly by bone cells of the osteoblast lineage, and their production is highly regulated. Of particular importance for a potential role in the pathogenesis of osteoporosis are two recent sets of observations. The first is that sex hormones can regulate PG production in bone. This may be relevant because hormone deficiency is so important in the pathogenesis of osteoporosis. The second is that mechanical forces can alter PG production by bone cells and that some of the responses to changes in mechanical force in vitro and in organ culture may be mediated by PG.

In this paper we will summarize the salient facts concerning the effects of PG's on bone and the regulation of PG synthesis by bone cells. A more detailed analysis of PG effects is available from earlier reviews.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Raisz, L. G. and Martin, T. J.: In: Bone and Mineral Research, Annual 2 (W. A. Peck ed.), pp. 286, 1983.

  2. Harvey, W. and Bennett, A.: In: Prostaglandins in Bone Resorption, CRC Press, pp. 134, 1988.

  3. Fuller, K. and Chambers, T. J.: J. Bone Min. Res. 4, 209, 1989.

    CAS  Google Scholar 

  4. Conaway, H. H., Diez, L. F. and Raisz, L. G.: Calcified Tissue Int. 38, 130, 1986.

    CAS  Google Scholar 

  5. Lerner, U. H., Ransjo, M. and Ljunngren, O.: Calcified Tissue Int. 40, 323, 1987.

    CAS  Google Scholar 

  6. McCarthy, T. L., Centrella, M., Raisz, L. G. and Canalis, E.: J. Bone Min. Res. 5(S2), 49A. (Abstract), 1990.

  7. Poznanski, A. K., Fernbach, S. K. and Berry T. E.: Skeletal Radiol. 14, 20, 1985.

    Article  CAS  PubMed  Google Scholar 

  8. Jee, W. S. S., Ueno, K., Deng, Y. P. and Woodbury, D. M.: Calcified Tissue Int. 37, 148, 1985.

    CAS  Google Scholar 

  9. Fell, H. B. and Weiss, L.: J. Exp. Med. 121, 551, 1965.

    Article  CAS  PubMed  Google Scholar 

  10. Raisz, L. G. et al.: Science 185, 789, 1974.

    CAS  PubMed  Google Scholar 

  11. Tashjian, A. H. Jr., Voelkel, E. F., Lazzaro, M., Singer, F. R., Roberts, A. B., Derynck, R., Winkler, M. E. and Levine, L.: Proc. Natl. Acad. Sci. USA 82, 4535, 1985.

    CAS  PubMed  Google Scholar 

  12. Tashjian, A. H. Jr, Voelkel, E. F., Lazzaro, M., Goad, D., Bosma, T. and Levine, L.: Endocrinology 120, 2029, 1987.

    CAS  PubMed  Google Scholar 

  13. Tashjian, A. H. Jr. and Levine, L.: Biochem. Biophys. Res. Commun. 85, 966, 1987.

    Google Scholar 

  14. Raisz, L. G. and Simmons H. A.: Endocrine Res. 11, 59, 1985.

    CAS  Google Scholar 

  15. Klein Nulend, J., Aaron, J. N., Harrison, J. R., Simmons, H. A. and Raisz, L. G.: J. Bone Min. Res. 4(S1), 660A. (Abstract), 1989.

  16. Gowen, M. and Mundy, G. R.: J. Immunol. 136, 2478–2482, 1986.

    CAS  PubMed  Google Scholar 

  17. Peterlik, M., Hoffman, O., Swetly, P., Klaushofer, K. and Koller K.: FEBS 185, 287, 1985.

    Article  CAS  Google Scholar 

  18. Sato, K., Fujii, Y., Kasono, K., Saji, M., Tsushima, T. and Shizume, K.: Biochem. Biophys. Res. Commun. 138, 618, 1986.

    Article  CAS  PubMed  Google Scholar 

  19. Boyce, B. F., Aufdemorte, T. B., Garrett, I. R., Yates, A. J. P., Mundy, G. R.: Endocrinology 125, 1142, 1989.

    CAS  PubMed  Google Scholar 

  20. Pfeilschifter, J., Pignat, W., Vosbeck, K. and Marki, F.: Biochem. Biophys. Res. Commun. 159, 385, 1989.

    Article  CAS  PubMed  Google Scholar 

  21. Raz, A., Wyche, A., Seigel, N. and Needleman, P.: J. Biol. Chem. 263, 3022, 1988.

    CAS  PubMed  Google Scholar 

  22. Klein-Nulend, J., Fall, P. M. and Raisz L. G.: Endocrinology 126, 223, 1990.

    CAS  PubMed  Google Scholar 

  23. Klein-Nulend, J. and Raisz L. G.: Calcified Tissue Int. 46(S2), 83A. (Abstract) 1990.

  24. Akatsu, T., Takahashi, N., Debari, K., et al.: J. Bone Min. Res. 4, 29, 1989.

    CAS  Google Scholar 

  25. Shinar, D. M. and Rodan, G. A.: Endocrinology 126, 3153, 1990.

    CAS  PubMed  Google Scholar 

  26. Harrison, J. R., Simmons, H. A., Lorenzo, J. A., Kream, B. E. and Raisz, L. G.: J. Bone Min. Res. 4(S1), 664A. (Abstract) 1989.

    Google Scholar 

  27. Marusic, A., Kalinowski, J. F., Harrison, J. R., Centrella, M. and Lorenzo, J. A.: J. Bone Min. Res. 5(S2), 312A. (Abstract) 1990.

  28. Bonewald, L. F. and Mundy, G. R.: Clin. Orthop. 250, 261, 1990.

    PubMed  Google Scholar 

  29. Marcelli, C., Yates, A. J. and Mundy, G. R.: J. Bone Min. Res. 5, 1087, 1990.

    CAS  Google Scholar 

  30. Feyen, J. H. M. and Raisz, L. G.: Endocrinology 121, 819, 1987.

    CAS  PubMed  Google Scholar 

  31. Pilbeam, C. C., Klein-Nulend, J. and Raisz, L. G.: Biochem. Biophys. Res. Commun. 163, 1319, 1989.

    Article  CAS  PubMed  Google Scholar 

  32. Pilbeam, C. C. and Raisz, L. G.: J. Bone Min. Res. 5, 1183, 1990.

    CAS  Google Scholar 

  33. Lane, N., Coble, T. and Kimmel, D. B.: J. Bone Min. Res. 5, 10, 1990.

    Google Scholar 

  34. Murray, D. W. and Rushton, N.: Calcified Tissue Int. 47, 35, 1990.

    CAS  Google Scholar 

  35. Thompson, D. D. and Rodan, G. A.: J. Bone Min. Res. 3, 409, 1988.

    CAS  Google Scholar 

  36. Pead, M. J. and Lanyon, L. E.: Calcified Tissue Int. 45, 34, 1989.

    CAS  Google Scholar 

  37. El Haj, A. J., Minter, S. L., Rawlinson, S. C. F., Suswillo, R. and Lanyon, L. E.: J. Bone Min. Res. 5, 923, 1990.

    Google Scholar 

  38. Reich, K. M., Gay, C. V. and Frangos, J. A.: J. Cell Physiol. 143, 100, 1990.

    Article  CAS  PubMed  Google Scholar 

  39. Raisz, L. G., Simmons, H. A. and Fall, P. M.: Prostaglandins 37, 559, 1989.

    CAS  PubMed  Google Scholar 

  40. Williams, R. C., Jeffcoat, M. K., Howell, T. H., Reddy, M. S., Johnson, H. G., Hall, C. M. and Goldhaber, P.: J. Period. Res. 23, 225, 1988.

    CAS  Google Scholar 

  41. Hopps, R. M., Nuki, K. and Raisz, L. G.: Calcified Tissue Int. 31, 239–245, 1980.

    CAS  Google Scholar 

  42. Meghji, S., Sandy, J. R., and Scutt, A. M., et al.: Prostaglandins 36, 139, 1988.

    Article  CAS  PubMed  Google Scholar 

  43. Fukase, M., Yamada, H., Tsutsumi, M., Fujimori, A., Fujita, T.: International Symposium on Osteoporosis and Lipids. October 26–27, Pg. 23, 1990.

Download references

Author information

Authors and Affiliations

  1. University of Connecticut Health Center, 06032, Farmington, CT, USA

    Lawrence G. Raisz, Carol C. Pilbeam, Jenneke Klein-Nulend & John R. Harrison

Authors
  1. Lawrence G. Raisz
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Carol C. Pilbeam
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jenneke Klein-Nulend
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. John R. Harrison
    View author publications

    You can also search for this author in PubMed Google Scholar

About this article

Cite this article

Raisz, L.G., Pilbeam, C.C., Klein-Nulend, J. et al. Effects and regulation of prostaglandins in bone: Possible implications for the pathogenesis of osteoporosis. J Bone Miner Metab 9, 39–44 (1991). https://doi.org/10.1007/BF02377984

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02377984

Keywords

Search

Navigation