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Cytokines and bone remodeling

  • 4. Inter- And Intracellular Signal Transduction In Osteoporosis
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References

  • Abe, E., Tanaka, H., Ishimi, Y., Miyayra, C., and others, Differentiation-inducing factor purified from conditioned medium of mitogen-treated spleen cell cultures stimulates bone resorption. Proc. Natl. Acad. Sci. 83: 5958–5962, 1986.

    CAS  PubMed  Google Scholar 

  • Bataille, R., Jourdan, M., Zhang, X. G., Klein, B., Serum levels of interleukin-6, a potent myeloma cell growth factor, as a reflect of disease severity in plasma cell dyscrasias, J. Clin. Invest. 84: 2008–2011, 1989.

    CAS  PubMed  Google Scholar 

  • Bentz, H., Nathan, R. M., Rosen, D. M., Armstrong, R. M., and others, Purification and characterization of a unique osteoinductive factor from bovine bone. J. Biol. Chem. 264: 20805–20810, 1989.

    CAS  PubMed  Google Scholar 

  • Bertolini, D. R., Nedwin, G. E., Bringman, T. S., Mundy, G. R., Stimulation of bone resorption and inhibition of bone formation in vitro by human tumour necrosis factor. Nature 319: 516–518, 1986.

    Article  CAS  PubMed  Google Scholar 

  • Black, K., Mundy, G. R., Garrett, I. R., Interleukin-6 causes hypercalcemia in vivo, and enhances the bone resorbing potency of interleukin-1 and tumor necrosis factor by two orders of magnitude in vitro. J. Bone Min. Res. (in press).

  • Bolander, M. E., Joyce, M. E., Boden, S. D., Oliver, B., Heydemann, A., Estrogen receptor mRNA expression during fracture healing in the rat detected by polymerase chain reaction amplification. J. Bone Min. Res. 4: #567, 1989.

  • Boyce, B. R., Aufdemorte, T. B., Garrett, I. R., Yates, A. J. P., Mundy, G. R., Effects of interleukin-1 on bone turnover in normal mice. Endo 125: 1142–1150, 1989.

    CAS  Google Scholar 

  • Boyce, B. R., Yates, A. J. P., Mundy, G. R., Bolus injections of recombinant human interleukin-1 cause transient hypocalcemia in normal mice. Endo crinol. 125: 2780–2783, 1989.

    CAS  Google Scholar 

  • Carter, D. B., Deibel, M. R., Dunn, C. J., Tomich, C. S. C., Laborde, A. L., Slightom, J. L., Berger, A. E., Bienkowski, M. J., Sun, F. F., McEwan, R. N., Harris, P. K. W., Yem, A. W., Waszak, G. A., Chosay, J. G., Sieu, L. C., Hardee, M. M., Zurcher-Neely, H. A., Reardon, I. M., Heinrikson, R. L., Truesdell, S. E., Shelly, J. A., Eessalu, T. E., Taylor, B. M., Tracey, D. E., Purification, cloning, expression and biological characterization of an interleukin-1 receptor antagonist protein. Nature 344: 633–638, 1990.

    Article  CAS  PubMed  Google Scholar 

  • Canalis, E., Interleukin-1 has independent effects on deoxyribonucleic acid and collagen synthesis in cultures of rat calvariae. Endo. 118: 74–81, 1986.

    CAS  Google Scholar 

  • Canalis, E., Centrella, M., Burch, W., McCarthy, T. L., Insulin-like growth factor I mediates selective anabolic effects of parathyroid hormone in bone cultures. J. Clin. Invest. 83: 60–65, 1989.

    CAS  PubMed  Google Scholar 

  • Chenu, C., Pfeilschifter, J., Mundy, G. R., Roodman, G. D., Transforming growth factor beta inhibits formation of osteoclast-like cells in long-term human marrow cultures. Proc. Natl. Acad. Sci. 85: 5683–5687, 1988.

    CAS  PubMed  Google Scholar 

  • Chizzonite, R., Truitt, T., Kilian, P. L., Stern, A. S., and others, Two high-affinity interleukin-1 receptors represent separate gene products. Proc. Natl. Acad. Sci. USA 86: 8029–8033, 1989.

    CAS  PubMed  Google Scholar 

  • Garrett, I. R., Black, K. S., Mundy, G. R., Interactions between interleukin-6 and interleukin- 1 in osteoclastic bone resorption in neonatal mouse calvariae. Calcif. Tiss. Int. (1990a) in press.

  • Garrett, I. R., Boyce, B. F., Oreffo, R. O. C., Bonewald, L., Poser, J., Mundy, G. R., Oxygen- derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo. J. Clin. Invest. 85: 632–639, 1990.

    CAS  PubMed  Google Scholar 

  • Gowen, M., Meikle, M. C., Reynolds, J. J., Stimulation of bone resorption in vitro by a nonprostanoid factor released by human monocytes in culture. Biochem. Biophys. Acta 762: 471–474, 1983.

    CAS  PubMed  Google Scholar 

  • Gowen, M., Mundy, G. R., Actions of recombinant interleukin- 1, interleukin-2 and interferon gamma on bone resorption in vitro. J. Immunol. 136: 2478–2482, 1986.

    CAS  PubMed  Google Scholar 

  • Gowen, M., Nedwin, G., Mundy, G. R., Preferential inhibition of cytokine stimulated bone resorption by recombinant interferon gamma. J. Bone Min. Res. 1: 469–474, 1986. Hauschka, P. W., Mavrakos, A. E., Iafrati, M. D., Doleman, S. E., Klagsbrun, M., Growth factors in bone matrix. J. Biol. Chem. 261: 12665– 12674, 1986.

    CAS  Google Scholar 

  • Johnson, R. A., Boyce, B. F., Mundy, G. R., Roodman, G. D., Tumors producing human TNF induce hypercalcemia and osteoclastic bone resorption in nude mice. Endo 124: 1424–1427, 1989.

    CAS  Google Scholar 

  • Joyce, M. E., Jingushi S, Roberts, A. B., Sporn, M. B., Bolander, M. E., Transforming growth factor β initiates cartilage and bone formation in vivo. J. Bone Min. Res. 4: #566, 1989.

  • Kukita, A., Bonewald, L., Rosen, D., Seyedin, S., Mundy G. R., Roodman, G. D., Osteoinductive factor inhibits formation of human osteoclast-like cells. Proc. Natl. Acad. Sci. USA 87: 2023–2026, 1990.

    Google Scholar 

  • Marcelli, C., Yates, A. J. P., Mundy, G. R., In vivo effects of human recombinant transforming growth factor beta on bone turnover in normal mice. J. Bone Min. Res. (in press), 1990.

  • Noda, M., Camilliere, J. J., In vivo stimulation of bone formation by transforming growth factor beta. Endo. 124: 2991–2994, 1989.

    CAS  Google Scholar 

  • Oreffo, R. O. C., Bonewald, L., Kukita, A., Garrett, I. R., Seyedin, S. M., Rosen, D., Mundy, G. R., Inhibitory effects of the bone- derived growth factors osteoinductive factor and transforming growth factor β on isolated osteoclasts. Endo. 126: 3069–3075, 1990.

    CAS  Google Scholar 

  • Pfeilschifter, J. P., Seyedin, S., Mundy, G. R., Transforming growth factor beta inhibits bone resorption in fetal rat long bones. J. Clin. Invest. 82: 680–685, 1988.

    CAS  PubMed  Google Scholar 

  • Pfeilschifter, J., Mundy, G. R., Roodman, G. D., Interleukin-1 and tumor necrosis factor stimulate the formation of human osteoclast- like cells in vitro. J. Bone Min. Res. 4: 113, 1989.

    CAS  Google Scholar 

  • Reid, T. R., Torti, F. M., Ringold, G. M., Evidence for 2 mechanisms by which tumor necrosis factor kills cells. J. Biol. Chem. 264: 4583–4589, 1989.

    CAS  PubMed  Google Scholar 

  • Sabatini, M., Boyce, B., Aufdemorte, T., Bonewald, L., Mundy, G. R., Infusions of recombinant human interleukin- 1 alpha and beta cause hypercalcemia in normal mice. Proc. Natl. Acad. Sci. 85: 5235–5239, 1988.

    CAS  PubMed  Google Scholar 

  • Suda, T., Miyaura, C., Ishimi, Y., et al, The role of differentiation-inducing factors (DIFs) in bone metabolism, In: X International Conference on Calcium Regulating Hormones, (Elsevier, Amsterdam, 1989), in press.

    Google Scholar 

  • Takahashi, N., Mundy, G. R., Roodman, G. D., Recombinant human interferon gamma inhibits formation of human osteoclast like cells. J. Immunol. 137: 3544–3549, 1986.

    CAS  PubMed  Google Scholar 

  • Tashjian, A. H., Voelkel, E. F., Lloyd, W., Derynck, R., Winkler, M. E., Levine, L., Actions of growth factors on plasma calcium. J. Clin. Invest. 78: 1405–1409, 1986.

    CAS  PubMed  Google Scholar 

  • Tashjian, A. H., Voelkel, E. F., Lazzaro, M., Goad, D., Bosma, T., Levine, L., Tumor necrosis factor α (cachectin) stimulates bone resorption in mouse calvaria via a prostaglandin- mediated mechanism. Endo. 120: 2029–2036, 1987.

    CAS  Google Scholar 

  • Thomson, B. M., Saklatvala, J., Chambers, T. J., Osteoblasts mediate interleukin- 1 stimulation of bone resorption by rat osteoclasts. J. Exp. Med. 164: 104–112, 1986.

    Article  CAS  PubMed  Google Scholar 

  • Thomson, B. M., Mundy, G. R., Chambers, T. J., Tumor necrosis factors α and β induce osteoblastic cells to stimulate osteoclastic bone resorption. J. Immunol. 138: 775–779, 1987.

    CAS  PubMed  Google Scholar 

  • Wozney, J. M., Rosen, V., Celeste, A. J., Mitsock, L. M., and others. Novel regulators of bone formation: molecular clones and activities. Science 242: 1528–1534, 1988.

    CAS  PubMed  Google Scholar 

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Mundy, G.R. Cytokines and bone remodeling. J Bone Miner Metab 9, 34–38 (1991). https://doi.org/10.1007/BF02377983

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