Rapidly progressive osteopenia in the oophorectomized and nutrition deprived rats
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Eight-week old healthy female Wistar rats were oophorectomized and placed on a low calcium-low protein diet. Histological analysis showed evidence of osteopenia after 7 days. The bone ash calcium content was reduced at 4 weeks. This rapidly progressive bone loss was apparently related to active osteoclastic bone resorption following a nutrition-related secondary hyperparathyroidism. Abnormal large osteoid and osteitis fibrosa were absent. These skeletal alterations resemble findings in case of osteopenia in postmenopausal women.
Key WordsOsteoporosis oophorectomy-hyperparathyroidism-osteoclast-rat
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