Journal of Bone and Mineral Metabolism

, Volume 7, Issue 1, pp 12–16 | Cite as

Rapidly progressive osteopenia in the oophorectomized and nutrition deprived rats

  • Kanji Fukuda
  • Seisuke Tanaka
  • Haruhiko Yamasaki
  • Hikaru Hayashi
Original Articles


Eight-week old healthy female Wistar rats were oophorectomized and placed on a low calcium-low protein diet. Histological analysis showed evidence of osteopenia after 7 days. The bone ash calcium content was reduced at 4 weeks. This rapidly progressive bone loss was apparently related to active osteoclastic bone resorption following a nutrition-related secondary hyperparathyroidism. Abnormal large osteoid and osteitis fibrosa were absent. These skeletal alterations resemble findings in case of osteopenia in postmenopausal women.

Key Words

Osteoporosis oophorectomy-hyperparathyroidism-osteoclast-rat 


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Copyright information

© Japanese Society of Bone Metabolism Research 1989

Authors and Affiliations

  • Kanji Fukuda
    • 1
  • Seisuke Tanaka
    • 1
  • Haruhiko Yamasaki
    • 1
  • Hikaru Hayashi
    • 1
  1. 1.Department of Orthopaedic SurgeryKinki University School of MedicineOsakaJapan

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