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The regulation of parathyroid hormone in health and in chronic renal failure

  • Workshop On PTH And Renal Osteodystorophy July 14, 1990 Hotel Paciffic Meridian Tokyo, Japan
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References

  1. Lopez-Hilker S, Galceran T, Chan TL, Rapp N, Martin K, Slatopolsky E.: Hypocalcemia may not be essential for the development of secondary hyperparathyroidism in chronic renal failure. J Clin Invest 78:1097–1102,1986.

    CAS  PubMed  Google Scholar 

  2. Keutmann HT, Sauer MM, Hendry GN, O'Riordan JLH, Potts JT Jr: Complete amino-acid sequence of human parathyroid hormone. Biochem 17:5723–5729,1978.

    CAS  Google Scholar 

  3. Habener JF, Potts JT Jr, Rich A: Pre-proparathyroid hormone: Evidence for an early biosynthetic precursor of proparathyroid hormone. J Biol Chem 251:3893–3989,1976.

    CAS  PubMed  Google Scholar 

  4. Habener JF, Rosenblatt M, Kemper B, Kronenberg HM, Rich A, Potts JT Jr: Pre proparathyroid hormone: Amino acid sequence, chemical synthesis, and some biological studies of the precursor region. Proc Nat Acad Sci USA 2616–2620,1978.

  5. Chu LL, MacGregor RR, Hamilton JW, Cohn DV: Conversion of proparathyroid harmone to parathyroid hormone: The use of amines as specific inhibitors. Endocrinology 95:1431–1438, 1974.

    CAS  PubMed  Google Scholar 

  6. Oldham SB, Fischer JA, Shen LH, Arnaud CD: Isolation and properties of a calcium-binding protein from porcine parathyroid glands. Biochem 13:4790–4796,1974.

    CAS  Google Scholar 

  7. Brunbaugh PF, Hughes MR, Haussler MR: Cytoplasmic and nuclear binding components for I alpha, 25-dihydroxyvitamin D3 in chick parathyroid glands. Proc Natl Acad Sci USA 72:4871–4875,1975.

    Google Scholar 

  8. Henry HL, Norman AW: Studies on the mechanism of action of calciferol. VII. Localization of 1,25-dihydroxyvitamin D3 in chick parathyroid glands. Biochem Biophys Res Commun 62:781–788,1975.

    CAS  PubMed  Google Scholar 

  9. Chertow BS, Baker GR, Henry HL, Norman AW: Effects of vitamin D metabolites on bovine parathyroid hormone release in vitro. Am J Physiol 238:E384-E388,1980.

    CAS  PubMed  Google Scholar 

  10. Nko M, Gruson M, Gueris J, Mouktar MS, Redel J, Demignon J, Miravet L: Effects of vitamin D3 dihydroxylated metabolites on parathyroid hormone in the rat in in vitro studies with dispersed rat parathyroid cells. Miner Electrol Metab 7:67–75,1982.

    CAS  Google Scholar 

  11. Canterbury JM, Lerman S, Claflin AJ, Henry H, Norman A, Reiss E: Inhibition of parathyroid hormone secretion by 25 dihydroxycholecalciferol and 24,25-dihydroxycholecalciferol in the dog. J Clin Invest. 61:1375–1383,1978.

    CAS  PubMed  Google Scholar 

  12. Llach F, Coburn JW, Brickman AS, Kurokawa K, Norman AW, Canterbury JM, Reiss E: Acute actions of 1,25 dihydroxyvitamin D3 in normal man: Effect on calcium and parathyroid status. J. Clin Endocrinol Metab. 44:1054–2060,1977.

    CAS  PubMed  Google Scholar 

  13. Tanaka Y, DeLuca HF, Ghazarian JG, Hargis GK, Williams GA: Effect of vitamin D and its metabolites on serum parathyroid hormone levels in the rat. Miner. Electrol. Metab. 2:20–25,1979.

    CAS  Google Scholar 

  14. Golden P, Greenwalt A, Martin K, Bellorin Font E, Mazey R, Klahr E.: Slatopolsky Sl Lack of direct effect of 1,25-dihydroxycholecalciferol on parathyroid hormone secretion by normal bovine parathyroid glands. Endocrinology 107:602–607,1980.

    CAS  PubMed  Google Scholar 

  15. Chan YL, McKay C, Dye E, Slatopolsky E.: The effect of 1,25-dihydroxycholecalciferol on parathyroid hormone secretion by monolayer cultures of bovine parathyroid cells. Calcif. Tissue Int. 38:27–32,1986.

    CAS  PubMed  Google Scholar 

  16. Silver J, Russell J, Sherwood LM: Regulation by vitamin D metabolites of messenger RNA for pre proparathyroid hormone in isolated bovine parathyroid cells. Proc. Natl. Acad. Sci. USA 82:4270–4273,1985.

    CAS  PubMed  Google Scholar 

  17. Cantley LK, Russell D, Lettieri, Sherwood LM: 1,25-Dihydroxyvitamin D3 suppresses PTH secretion from bovine parathyroid cells in tissue culture. Endocrinology 227:2114–2119,1985.

    Google Scholar 

  18. Silver J, Naveh Many T, Mayer H, Schmeizer HJ, Popovtzer MM: Regulation by vitamin D metabolies of parathyroid gene transcription in vivo in the rat. J. Clin Invest 78:1296–1301,1986.

    CAS  PubMed  Google Scholar 

  19. Russell J, Lettieri D, Sherwood LM: Suppression by 1,25-(OH)2D3 of transcription of the parathyroid gene. Endocrinology 119:2864–2866,1986.

    CAS  PubMed  Google Scholar 

  20. Okazaki T, Igarashi T, Kronenberg HM: 5′ Flanking region of the parathyroid hormone gene mediates negative regulation by 1,25 (OH)2 vitamin D3. J. Biol. Chem. 263:2203–2208,1988.

    CAS  PubMed  Google Scholar 

  21. Russell J, Sherwood LM: The effects of 1,25 dihydroxyvitamin D3 and high calcium on transcription of the pre-pro-parathyroid hormone gene are direct. Trans Assoc Am Phys 100:256–262,1987.

    CAS  PubMed  Google Scholar 

  22. Yamamoto M, Igarashi T, Muramatsu M, Fukagawa EM, Motokura T, Ogata E: Hypocalcemia increases and hypercalcemia decreases the steady state level of parathyroid hormone messenger RNA in the rat. J. Clin. Invest. 83:1053–1056,1989.

    CAS  PubMed  Google Scholar 

  23. Brown EM, Brennan MF, Hurwitz S, Windeck R, Marx SJ, Spiegel AM, Koehler JO, Gardner DG, Aurbach GD: Dispersed cells prepared from human parathyroid glands. Distinct calcium sensitivity of adenomas vs. primary hyperplasia. J. Clin. Endocrinol Metab. 46:267–275,1978.

    CAS  PubMed  Google Scholar 

  24. Brown EM, Wilkson RE, Eastman RC, Pallotta J, Marynick SP: Abnormal regulation of parathyroid hormone release by calcium in secondary hyperparathyroidism due to chronic renal failure. J. Clin. Endocrinol Metab. 54:172–179,1982.

    CAS  PubMed  Google Scholar 

  25. Bellorin Font E, Martin KJ, Freitag JJ, Anderson C, Sicard G, Slatopolsky E, Klahr S: Altered adenylate cyclase kinetics in hyperfunctioning human parathyroid glands. Comparison with normal human and bovine parathyroid tissue. J. Clin. Endocrinol 52:499–507,1981.

    CAS  Google Scholar 

  26. Slatopolsky E., Gray R, Adams N, Lewis J, Hruska K, Martin K, Klahr S, DeLuca H, Lemann J: The pathogenesis sf secondary hyperparathyroidism in early renal failure; in Norman, Vitamin D: Basic research and its clinical application (deGruyter, Berlin), 1979.

  27. Madsen S, Olgaard K, Ladefoged J: Suppressive effect of 1,25-dihydroxyvitamin D3 on circulating parathyroid hormone in acute renal failure. J. Clin. Endocrinol Metab. 53:823–827,1981.

    CAS  PubMed  Google Scholar 

  28. Slatopolsky E., Weerts C, Thielan J, Horst R, Harter H, Martin K: Marked suppression of secondary hyperparathyroidism by intravenous administration of 1,25-dihydroxycholecalciferol in uremic patients. J. Clin. Invest. 74:2136–2143,1984.

    CAS  PubMed  Google Scholar 

  29. Hunziker W, Walters MR, Bishop JE, Norman AW: Effect of vitamin D status on equilibrium between occupied and unoccupied 1,25-dihydroxyvitamin D intestinal receptors in the chick. J. Clin. Invest. 69:826–834,1981.

    Google Scholar 

  30. Chen TL, Hauschka PV, Cabrales S, Feldman D: The effects of 1,25-dihydroxyvitamin D3 and dexamethasone on rat osteoblast-like primary cell cultures: Receptor occupancy and functional expression patterns for three different bioresponses. Endocrinology 118:250–259,1986.

    CAS  PubMed  Google Scholar 

  31. Korkor AB: Reduced binding of [3H] 1,25 dihydroxyvitamin D3 in the parathyroid glands of patients with renal failure. N. Engl. J. Med. 316:1573–1577,1987.

    CAS  PubMed  Google Scholar 

  32. Merke J, Hugel U, Zlotkowski A, Szabo A, Bommer J, Mall G, Ritz E: Diminished parathyroid 1,25-(OH)2D3 receptors in experimental uremia. Kidney Int. 32:350–353,1987.

    CAS  PubMed  Google Scholar 

  33. Brown AJ, Dusso A, Lopez-Hilker S, Lewish Finch J, Grooms P, Slatopolsky E: 1,25-(OH)2D receptors are decreased in parathyroid glands from chronically uremic dogs. Kidney Int. 35:19–23,1989.

    CAS  PubMed  Google Scholar 

  34. Naveh-Many T, Marx R, Keshet E, Pike JW, Silver J: Regulation of 1,25-Dihydroxyvitamin D3 receptor gene expression by 1,25-dihydroxyvitamin D3 in the parathyroid in vivo. J. Clin. Invest. 86:1968–1975,1990.

    CAS  PubMed  Google Scholar 

  35. Delmez JA, Tindira C, Grooms P, Dusso A, Windus DW, Slatopolsky E.: Parathyroid hormone suppression by intravenous 1,25-dihydroxyvitamin D: A role for increased sensitivity to calcium. J. Clin. Invest. 83:1349–1355, 1989.

    CAS  PubMed  Google Scholar 

  36. Dunlay R, Rodriguez M, Felsenfeld AJ, Llach F: Direct inhibitory effect of calcitriol on parathyroid function (sigmoidal curve) in dialysis. Kidney Int. 36:1093–1098,1989.

    CAS  PubMed  Google Scholar 

  37. Bricker NS, Slatopolsky E., Reiss E, Avioli LV: Calcium, phosphorus and bone in renal disease and transplantation. Arch. Intern Med. 123:543–553,1969.

    Article  CAS  PubMed  Google Scholar 

  38. Slatopolsky E., Caglar S, Pennell JP, Taggart DD, Canterbury JM, Reiss E, Bricker NS: On the pathogenesis of hyperparathyroidism in chronic experimental renal insufficiency in the dog. J. Clin. Invest. 50:492–499,1971.

    CAS  PubMed  Google Scholar 

  39. Slatopolsky, E, Caglar S, Gradowska L, Canterbury J, Reiss E, Bricker NS: On the prevention of secondary hyperparathyroidism in experimental chronic renal disease using “proportional reduction” of dietary phosphorus intake. Kidney Int. 2:147–151,1972.

    CAS  PubMed  Google Scholar 

  40. Portale AA, Booth BE, Halloran BP, Morris RC Jr: Effect of dietary phosphorus on circulating concentrations of 1,25-dihydroxyvitamin D and immunoreactive parathyroid hormone in children with moderate renal insufficiency. J. Clin. Invest. 73:1580–1589,1984.

    CAS  PubMed  Google Scholar 

  41. Lucas PA, Brown RC, Woodhead JS, Coles GA: 1,25-dihydroxycholecalciferol and parathyroid hormone in advanced chronic renal failure: effects of simultaneous protein and phosphorus restriction. Clin. Nephrol. 25:7–10,1986.

    CAS  PubMed  Google Scholar 

  42. Lopez-Hilker S, Dusso AS, Rapp NS, Martin KJ, Slatopolsky E.: Phosphorus restriction reverses hyperparathyoidism in uremia independent of changes in calcium and calcitriol. Am J. Physiol. 259:F432-F437,1990.

    CAS  PubMed  Google Scholar 

  43. Tsukamoto Y, Nomina M, Marumo I: Pharmacological parathyroidectomy by oral 1,25-(OH)2D3 pulse therapy (letter). Nephron 51:130–131,1989.

    CAS  PubMed  Google Scholar 

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  1. One Barnes Hospital Plaza, Washington University School of Medicine Chromalloy American Kidney Center, Box 8129, 63110, St.Louis, MO

    Eduardo Slatopolsky M.D.

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Slatopolsky, E. The regulation of parathyroid hormone in health and in chronic renal failure. J Bone Miner Metab 9, 39–44 (1991). https://doi.org/10.1007/BF02374905

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