Skip to main content

Advertisement

SpringerLink
Log in

Quantification of bone mineral contents using dual photon absorptiometry in a normal Japanese population — total body bone mineral

  • Original Article
  • Published:
Journal of Bone and Mineral Metabolism Aims and scope Submit manuscript

Abstract

We established reference values for total body bone mineral of normal Japanese subjects utilizing dual photon absorptiometry. The index of measurement, total body bone mineral content (TBBM) divided by lean body mass (LBM), might be suitable for the evaluation of total body bone mineral. TBBM/LBM did not correlate with age in male subjects; however, reduced bone mineral was noted in female subjects after fifth decade. The rate of change in bone after the fifth decade was 0.82% per year. The bone mineral density (BMD) of each region including total body also showed a significant decrease with aging in women after the age of 40. Again no significant age-related changes were obtained in male BMD of any region (head, trunk, pelvis, legs, arms). The annual loss in women after the bone loss began was 0.72% in total body BMD. The rate of BMD change in each region of bone after 40 years of age ranged from 0.91% (trunk) to 0.51% (arms) per year. The bone mineral content (BMC) in “trunk” portion of TBBM decreased significantly with aging, while BMC of other portions did not show a significant age-related change. These results differ slightly from results which we have already reported for lumbar spine BMD, in which case average annual rates of bone loss once begun, were 0.32% for male and 0.97% for female.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Cameron, JR. and Sorenson, J. (1963): Measurement of bone mineral in vivo: An improved method. Science 142, 230–232, 1963

    CAS  PubMed  Google Scholar 

  2. Genant, H.K., Cann, C.E., Ettinger, B. and Gordan, C.S. (1982): Quantitative computed tomography of vertebral spongiosa: A sensitive method for detecting early bone loss after oophorectomy. Ann Intern Med 97, 699–705, 1982

    CAS  PubMed  Google Scholar 

  3. Wilson, C.R. and Madsen, M. (1977): Dichromatic absorptiometry of vertebral bone mineral content. Invest Radiol 12, 180–184, 1977

    CAS  PubMed  Google Scholar 

  4. Riggs, B.L., Wahner, H.W., Seeman, E., Offord, K.P., Dunn, W.L., Mazess, R.B., Johnton, K.A. and Melton, L.J. III. (1982): Changes in bone mineral density of the proximal femur and spine with aging: Differences between the postmenopausal and senile osteoporosis syndromes. J Clin Invest 70, 716–723, 1982

    CAS  PubMed  Google Scholar 

  5. Peppler, W.W. and Mazess, R.B. (1981): Total body bone mineral and lean body mass by dual photon absorptiometry. I. Theory and measurement procedure. Calcif Tissue Int 33, 353–359, 1981

    CAS  PubMed  Google Scholar 

  6. Mazess, R.B., Peppler, W.W., Chesnut, C.H. III, Nelp, W.B., Cohn, S.H. and Zanzi, I. (1981): Total body bone mineral and lean body mass by dual photon absorptiometry. II. Comparison with total body calcium by neutron activation analysis. Calcif Tissue Int 33, 361–363, 1981

    CAS  PubMed  Google Scholar 

  7. Chamberlain, M.J., Fremlin, J.H., Peters, D.K. and Philip, H. (1968): Total body calcium by whole body neutron activation analysis: A new technique for study of bone disease. Br Med J 2, 581–583, 1968

    CAS  PubMed  Google Scholar 

  8. Manzke, E. Chesnut, C.H. III, Wergedal, J.E., Baylink, D.J. and Nelp, W.B. (1975): Relationship between local and total bone mass in osteoporosis. Metabolism 24, 605–615, 1975

    Article  CAS  PubMed  Google Scholar 

  9. Hagiwara, S., Miki, T., Nishizawa, Y., Ochi, H., Onoyama, Y. and Morii, H. (1989): Quantification of bone mineral content using dual photon absorptiometry in a normal Japanese population. J Bone Miner Res 4, 217–222, 1989

    CAS  PubMed  Google Scholar 

  10. Mazess, R.B., Peppler, W.W., Harrison, J.E. and McNeill, K.G. (1981): Total body bone mineral and lean body mass by dual photon absorptiometry. III. Comparison with trunk calcium by neutron activation analysis. Calcif Tissue Int 33, 365–368, 1981

    CAS  PubMed  Google Scholar 

  11. Eastel, R., Kennedy, N.S.J., Smith, M.A., Simpson, J.D., Strong, J.A. and Tothill, P. (1983): The assessment of postmenopausal osteoporosis by total body neutron activation analysis. Metab Bone Dis Relat Res 5, 65–67, 1983

    Google Scholar 

  12. Cohn, S.H., Ellis, K.J., Wallach, S., Zanzi, I., Atkins, H.L. and Aloia, J.F. (1974): Absolute and relative deficit in total skeletal calcium and radial bone mineral in osteoporosis. J Nucl Med 15, 428–435, 1974

    CAS  PubMed  Google Scholar 

  13. Gotfredsen, A., Borg, J., Christiansen, C. and Mazess, R.B. (1984): Total body mineral in vivo by dual photon absorptiometry. I. Measurement procedures. Clin Physiol 4, 343–355, 1984

    CAS  PubMed  Google Scholar 

  14. Gotfredsen, A., Hadberg, A., Nilas, L. and Christiansen, C. (1987): Total body bone mineral in healthy adults. J Lab Clin Med 110, 362–368, 1987

    CAS  PubMed  Google Scholar 

  15. Cohn, S.H., Vaswani, A., Zanzi, I. and Ellis, K.J. (1976): Effect of aging on bone mass in adult women. Am J Physiol 230, 143–148, 1976

    CAS  PubMed  Google Scholar 

  16. Riggs, B.L., Wahner, H.W., Dunn, W.L., Mazess, R.B., Offord, K.P. and Melton, L.J. III. (1981): Differential changes in bone mineral density of the appendicular and axial skeleton with aging. Relationship to spinal osteoporosis. J Clin Invert 67, 328–335, 1981

    CAS  Google Scholar 

  17. Aloia, J.F., Ross, P., Vaswani, A., Zanzi, I. and Cohn, S.H. (1982): Rate of bone loss in postmenopausal and osteoporotic women. Am J Physiol 242, E82–86, 1982

    CAS  PubMed  Google Scholar 

  18. Gallagher, J.C., Goldgar, D. and Moy, A. (1987): Total body calcium in normal women: Effect of age and menopause status. J Bone Miner Res 2, 491–496, 1987

    CAS  PubMed  Google Scholar 

  19. Wahner, H.W. (1989): Measurements of bone mass and bone density. Endocrinol Metab Clin North Am 18, 995–1012, 1989

    CAS  PubMed  Google Scholar 

  20. Fogelman, I., Rodin, A. and Blake, G. (1990): Impact of bone mineral measurements on osteoporosis. Eur J Nucl Med 16, 39–52, 1990

    Article  CAS  PubMed  Google Scholar 

  21. Genant, H.K., Steiger, P. Faulkner, K.G., Majumdar, S., Lang, P. and Gluer, C.C. (1990): Non-invasive bone mineral analysis: Recent advances and future directions. Osteoporosis 1990. (C. Christiansen, and K. Overgaard eds.) Osteopress ApS, Kobenhavn K, Denmark, pp. 435–441, 1990

    Google Scholar 

  22. Mazess, R.B., Peppler, W.W., Chesney, R.W., Lange, T.A. Lindgren, U. and Smith E. Jr. (1984): Total body and regional bone mineral by dual photon absorptiometry in metabolic bone disease. Calcif Tissue Int 36, 8–13, 1984

    CAS  PubMed  Google Scholar 

  23. Gotfredsen, A., Riis, B.J. and Christiansen, C. (1986): Total and local bone mineral during estrogen treatment: a placebo controlled trial. Bone Miner 1, 167–173, 1986

    CAS  PubMed  Google Scholar 

  24. Nuti, R., Righi, G., Turchetti, V., Martini, G. and Lepore, C. (1988): Total body and regional bone mineral analysis by dual-photon absorptiometry in Paget's disease of bone. Bone Miner 3, 359–367, 1988

    CAS  PubMed  Google Scholar 

  25. Hagiwara, S., Miki, T., Nakatsuka, K., Nishizawa, Y. and Morii, H. (1990): Bone mineral content in total body and lumbar spine using dual photon absorptiometry in diabetic and hemodialyzed patients. Bone Morphometry (H.E. Takahashi ed.), Nishimura Co. Ltd. Niigata, Japan, pp. 425–428, 1990

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Second Department of Internal Medicine, Osaka City University Medical School, Japan

    Satoshi Hagiwara, Takami Miki, Yoshiki Nishizawa & Hirotoshi Morii

  2. Department of Radiology, Osaka City University Medical School, Japan

    Hironobu Ochi

Authors
  1. Satoshi Hagiwara
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Takami Miki
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yoshiki Nishizawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Hironobu Ochi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Hirotoshi Morii
    View author publications

    You can also search for this author in PubMed Google Scholar

About this article

Cite this article

Hagiwara, S., Miki, T., Nishizawa, Y. et al. Quantification of bone mineral contents using dual photon absorptiometry in a normal Japanese population — total body bone mineral. J Bone Miner Metab 9, 25–30 (1991). https://doi.org/10.1007/BF02374903

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02374903

Key words

Search

Navigation