Skip to main content
Log in

Mechanism of action of 1,25-dihydroxyvitamin D3: 1990 version

  • Review
  • Published:
Journal of Bone and Mineral Metabolism Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. DeLuca, H. F. The transformation of a vitamin into a hormone: The vitamin D story. The Harvey Lectures, Series 75, pp. 333–379. Academic Press, New York (1981).

    Google Scholar 

  2. DeLuca, H. F. The vitamin D story: A collaborative effort of basic science and clinical medicine.FASEB J 2, 224–236 (1988).

    CAS  PubMed  Google Scholar 

  3. DeLuca, H. F. and H. K. Schoes. Vitamin D: Metabolism and mechanism of action. In: Ännual Reports in Medicinal Chemistry (D. M. Bailey, ed.), Chapter 18. Vol. 19, pp. 179–190. Academic Press, New York (1984).

    Google Scholar 

  4. Stumpf, W. E., M. Sar, S.A. Clark and H. F. DeLuca. Brain target sites for 1,25-dihydroxyvitamin D3.Science 215, 1403–1405 (1982).

    CAS  PubMed  Google Scholar 

  5. Stumpf, W. E., M. Sar, and H. F. DeLuca. Sites of action of 1,25-(OH)2 vitamin D3 identified by thaw-mount autoradiography. In: “Hormonal Control of Calcium Metabolism” (D. V. Cohn, R. V. Talmage, and J. L. Mattews, eds.), pp. 222–229. Excerpta Medica, Amsterdam (1981).

    Google Scholar 

  6. Halloran, B. P. and H. F. DeLuca. Intestinal calcium transport: Evidence for two distinct mechanisms of action of 1,25-dihydroxyvitamin D3.Arch. Biochem. Biophys. 208, 477–486 (1981).

    Article  CAS  PubMed  Google Scholar 

  7. Franceschi, R. T. and H. F. DeLuca. The effect of inhibitors of protein and RNA synthesis on 1α,25-dihydroxyvitamin D3 dependent calcium uptake in cultured embryonic chick duodenum.J. Biol. Chem. 256, 3848–3852 (1981).

    CAS  PubMed  Google Scholar 

  8. Link, R. and H. F. DeLuca. The vitamin D receptor. In: “The Receptors” (P. M. Conn, ed.), Vol. II, pp. 1–35. Academic Press, New York (1985).

    Google Scholar 

  9. DeLuca, H. F., J. Burmester, H. Darwish, and J. Krisinger. Molecular mechanism of action of 1,25-dihydroxyvitamin D3. In: “Comprehensive Medicinal Chemistry” (J. C. Emmett, ed.), Vol. 3, in press (1990).

  10. Brumbaugh, P. F. and M. R. Haussler. Nuclear and cytoplasmic binding components for vitamin D metabolites.Life Sci. 16, 353–362 (1975).

    Article  CAS  PubMed  Google Scholar 

  11. Kream, B. E., R. D. Reynolds, J. C. Knutson, J. A. Eisman, and H. F. DeLuca. Intestinal cytosol binders of 1,25-dihydroxyvitamin D3 and 25-hydroxyvitamin D3.Arch. Biochem. Biophys. 176, 779–787 (1976).

    Article  CAS  PubMed  Google Scholar 

  12. Simpson, R. U., A. Hamstra, N. C. Kendrick, and H. F. DeLuca. Purification of the receptor for 1α,25-dihydroxyvitamin D3 from chicken intestine.Biochemistry 22, 2586–2594 (1983).

    Article  CAS  PubMed  Google Scholar 

  13. Pike, J. W. and M. R. Haussler. Purification of chicken intestinal receptor for 1,25-dihydroxyvitamin D.Proc. Natl. Aca. Aci. USA 76, 5485–5489 (1979).

    CAS  Google Scholar 

  14. Pike, J. W., S. L. Marion, C. A. Donaldson, and M. R. Haussler. Serum and monoclonal antibodies against the chick intestinal receptor for 1,25-dihydroxyvitamin D3.J. Biol. Chem. 258, 1289–1296 (1983).

    CAS  PubMed  Google Scholar 

  15. Dame, M. C., E. A. Pierce, and H. F. DeLuca. Identification of the porcine intestinal 1,25-dihydroxyvitamin D3 receptor on sodium dodecyl sulfate-polyacrylamide gels by renaturation and immunoblotting.Proc. Natl. Acad. Aci. USA 82, 7825–7829 (1985).

    CAS  Google Scholar 

  16. Dame, M. C., E. A. Pierce, J. M. Prahl, C. E. Hayes, and H. F. DeLuca. Monoclonal antibodies to the porcine intestinal receptor for 1,25-dihydroxyvitamin D3: Interaction with distinct receptor domains.Biochemistry 25, 4523–4534 (1986).

    Article  CAS  PubMed  Google Scholar 

  17. Pierce, E. A., M. C. Dame, and H. F. DeLuca. Size and charge of the functional 1,25-dihydroxyvitamin D receptor in porcine intestine.J. Biol. Chem. 262, 17092–17099 (1987).

    CAS  PubMed  Google Scholar 

  18. Pike, J. W., N. M. Slearor, and M. R. Haussler. Chicken intestinal receptor for 1,25-dihydroxyvitamin D3. Immunologic characterization and homogeneous isolation of a 60,000-dalton protein.J. Biol. Chem. 262, 1305–1311 (1987).

    CAS  PubMed  Google Scholar 

  19. Burmester, J. K., N. Maeda, and H. F. DeLuca. Isolation and expression of rat 1,25-dihydroxyvitamin D3 receptor cDNA.Proc. Natl. Acad. Sci. USA 85, 1005–1009 (1988).

    CAS  PubMed  Google Scholar 

  20. McDonnell, D. P., D. J. Mangelsdorf, J. W. Pike, M. R. Haussler, and B. W. O'Malley. Molecular cloning of complementary DNA encoding the avian receptor dor vitamin D.Science 235, 1214–1217 (1987).

    CAS  PubMed  Google Scholar 

  21. Bumester, J. K., R. J. Wiese, N. Maeda, and H. F. DeLuca. Structure and regulation of the rat 1,25-dihydroxyvitamin D3 receptor.Proc. Natl. Acad. Sci. USA 85, 9499–9502 (1988).

    Google Scholar 

  22. Baker, A. R., D. P. McDonnell, M. Hughes, T. M. Crisp, D. J. Mangelsdorf, M. R. Haussler, J. W. Pike, J. Shine, and B. W. O' Malley. Cloning and expression of full-length cDNA encoding human vitamin D receptor.Proc. Natl. Acad. Sci. USA 85, 3294–3298 (1988).

    CAS  PubMed  Google Scholar 

  23. Brown, T. A., J. M. Prahl, and H. F. DeLuca. Partial amino acid sequence of porcine 1,25-dihydroxyvitamin D3 receptor isolated by immunoaffinity chromatography.Proc. Natl. Acad. Sci. USA 85, 2454–2458 (1988).

    CAS  PubMed  Google Scholar 

  24. Pike, J. W. and N. M. Sleator. Hormone-dependent phosphorylation of the 1,25-dihydroxyvitamin D3 receptor in mouse fibroblasts.Biochem. Biophys. Res. Commun. 131, 378–385 (1985).

    CAS  PubMed  Google Scholar 

  25. Lee, Y., M. Inaba, H. F. DeLuca, and W. S. Mellon. Immonological identification of 1,25-dihydroxyvitamin D3 receptor in human promyelocytic leukemic cells (HL-60) during homologous regulation.J. Biol. Chem. 262, 13701–13705 (1989).

    Google Scholar 

  26. Costa, E. M. and Feldman. Homologous up-regulation of the 1,25-(OH)2 vitamin D3 receptor in rats.Biochem. Biophys. Res. Commun. 137, 742–747 (1986).

    Article  CAS  PubMed  Google Scholar 

  27. Strom, M., M. E. Sandgren, T. A. Brown, and H. F. DeLuca. 1,25-dihydroxyvitamin D3 up-regulates the 1,25-dihydroxyvitamin D3 receptorin vivo.Proc. Natl. Acad. Sci. USA 86, 9770–9773 (1989).

    CAS  PubMed  Google Scholar 

  28. Krisinger, J., H. Darwish, N. Maeda, and H. F. DeLuca. Structure and nucleotide sequence of the rat intestinal vitamin D-dependent calcium binding protein gene.Proc. Natl. Acad. Sci. USA 85, 8988–8992 (1988).

    CAS  PubMed  Google Scholar 

  29. Perret, C., N. Lomri, N. Gouhier, C. Auffray, and M. Thomasset. The rat vitamin-D dependent calcium-binding protein (9-kDa CaBP) gene. Complete nucleotide sequence and structural organization.Eur. J. Biochem. 172, 43–51 (1988).

    Article  CAS  PubMed  Google Scholar 

  30. Price, P. A. and S. A. Baukol. 1,25-dihydroxyvitamin D3 increases synthesis of the vitamin D-dependent bone protein by osteosarcoma cells.J. Biol. Chem. 255, 11660–11666 (1980).

    CAS  PubMed  Google Scholar 

  31. Kerner, S. A., R. A. Scott, and J. W. Pike. Sequence elements in the human osteocalcin gene confer basal activation and inducible response to hormonal vitamin D3.Proc. Natl. Acad. Sci. USA 86, 4455–4459 (1989).

    CAS  PubMed  Google Scholar 

  32. DeMay, M. B., J. M. Gerardi, H. F. DeLuca, and H. M. Kronenberg. DNA sequences in the rat osteocalcin gene that bind the 1,25-dihydroxyvitamin D3 receptor and confer responsiveness to 1,25-dihydroxyvitamin D3.Proc. Natl. Acad. Sci. USA 87, 369–373 (1990).

    CAS  PubMed  Google Scholar 

  33. Morrison, N. A., J. Shine, J. C. Fragonas, V. Verkest, M. L. McMenemy, and J. A. Eisman. 1,25-dihydroxyvitamin D-responsive element and glucocorticoid repression in the osteocalcin gene.Science 246, 1158–1161 (1989).

    CAS  PubMed  Google Scholar 

  34. Abe, E., C. Miyaura, H. Sakagami, M. Takeda, K. Konno, T. Yamazaki, S. Yoshiki, and T. Suda. Differentiation of mouse myeloid leukemia cells induced by 1α,25-dihydroxyvitamin D3.Proc. Natl. Acad. Sci. USA 78, 4990–4994 (1981).

    CAS  PubMed  Google Scholar 

  35. Tanaka, H., E. Abe, C. Miyaura, T. Kuribayashi, K. Konno, Y. Nishii, and T. Suda. 1α,25-dihydroxycholecalciferol and a human myeloid leukaemia cell line (HL-60). The presence of a cytosol receptor and induction of differentiation.Biochem. J. 204, 713–719 (1982).

    CAS  PubMed  Google Scholar 

  36. Murayama, E., K. Miyamoto, N. Kubodera, T. Mori, and I. Matsunaga. synthetic studies of vitamin D3 analogues. VII. Synthesis of 22-oxavitamin D3 analogues.Chem. Phar. Bull. 34, 4410–4413 (1986).

    CAS  Google Scholar 

  37. Calverley, M. J. Synthesis of MC 903, a biologically active vitamin D metabolite analogue.Tetrahedron 43, 4606–4619 (1987).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

About this article

Cite this article

DeLuca, H.F. Mechanism of action of 1,25-dihydroxyvitamin D3: 1990 version. J Bone Miner Metab 8, 1–9 (1990). https://doi.org/10.1007/BF02374738

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02374738

Keywords

Navigation