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The influence of harmaline on the movements of sodium ions in smooth muscle of the guinea pig ileum

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Summary

The effect of changing the extracellular concentration of both Na+ and K+ on the longitudinal muscle of the guinea-pig ileum was studied in the presence and absence of harmaline. A decrease in extracellular Na+ concentration was found to produce a dose-dependent contractile response, which may suggest the existence of a Na...Ca exchange mechanism in this muscle. Harmaline (2 × 10−4 M) was found to reversibly inhibit this contraction and was also found to selectively block the tonic component of high-K induced contradictions. In view of the fact that harmaline is a non-competitive inhibitor of Ca-induced contractions (Hider et al., Europ. J. Pharmacol., 71, 87, 1981), the action of harmaline was interpreted as being a specific inhibitor of the Na... exchange mechanism, binding specifically to Na+ coordination sites.

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Authors and Affiliations

  1. Biology Department, An-Najah University, Nablus, West Bank, Israel

    Mohammed S. Suleiman

  2. Department of Chemistry, University of Essex, Colchester, UK

    Robert C. Hider

Authors
  1. Mohammed S. Suleiman
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  2. Robert C. Hider
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Suleiman, M.S., Hider, R.C. The influence of harmaline on the movements of sodium ions in smooth muscle of the guinea pig ileum. Mol Cell Biochem 67, 145–150 (1985). https://doi.org/10.1007/BF02370173

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  • DOI: https://doi.org/10.1007/BF02370173

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