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Modeling study on the distribution of flow and volume in the microcirculation of cat mesentery

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Abstract

In this paper, a method for the calculation of the distribution of vascular volume and flow in a repeating modular organization is presented. The calculation is based on the measured distribution of the mean transit time obtained by an indicator dilution technique. Several examples of the distributions of the vascular volume and flow are considered. The existence of higher flow in the capillaries more proximal to the large artery is demonstrated. The calculated volume for the perimeter vessels and for the capillaries agrees qualitatively with direct measurements.

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References

  • Chambers, R., andZweifach, B. W. Topography and function of the mesenteric circulation.American Journal of Anatomy, 1944,75, 173–205.

    Article  Google Scholar 

  • Frasher, W. G., Jr., andWayland, H. A repeating modular organization of the microcirculation of cat mesentery.Microvascular Research, 1972,4, 62–76.

    Article  PubMed  Google Scholar 

  • Groat, R. A. Relationship of volumetric rate of blood flow to arterial diameter.Federation Proceedings, 1948,7, 45.

    Google Scholar 

  • Jendrucko, R., and Lee, J. S. Photometric measurement of hematocrit in single microvessels, Ph. D. Thesis of University of Virginia, 1972.

  • Johnson, P. C. Red cell separation in the mesenteric capillary network.Journal of Applied Physiology, 1971,221, 99–104.

    CAS  Google Scholar 

  • Nellis, S. H. An application of a tracer dilution technique to cat mesenteric microcirculation, Ph. D. thesis, University of Virginia, 1972.

  • Nellis, S. H., and Lee, J. S. Dispersion of indicator measured from microvessels of cat mesentery.Circulation Research, 1974.

  • Renkin, E. M. Normal regulation of tissue circulation. InEffects of Anesthetics on the Circulation, (ed.), H. L. Price and P. J. Cohen; C. Thomas, Springfield, Ill., 1964, p. 171.

    Google Scholar 

  • Zierler, K. L. Circulation times and the theory of indicator dilution methods for determining blood flow and volume. InHandbook of Physiology, Section II. Circulation, Vol. 1., Ed., W. F. Hamilton and D. Dow,American Physiology Society, 1964, p. 585.

  • Zweifach, B. W. The structure and reaction of small blood vessels in amphibia.American Journal of Anatomy, 1937,60, 473–514.

    Article  Google Scholar 

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Authors and Affiliations

  1. Division of Biomedical Engineering, University of Virginia, 22901, Charlottesville, Virginia

    J. S. Lee & S. Nellis

Authors
  1. J. S. Lee
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  2. S. Nellis
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Additional information

This research was supported by Grants of USPHS, National Heart and Lung Institute HL 11747 and HL 14517. Part of this study was presented in the 4th Annual Conference of Biomedical Engineering Society, Los Angeles, California, 1973.

Supported by a post-doctoral fellowship of NIH.

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Lee, J.S., Nellis, S. Modeling study on the distribution of flow and volume in the microcirculation of cat mesentery. Ann Biomed Eng 2, 206–216 (1974). https://doi.org/10.1007/BF02368491

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  • DOI: https://doi.org/10.1007/BF02368491

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