Annals of Biomedical Engineering

, Volume 18, Issue 3, pp 263–283 | Cite as

Computer simulation of the mechanically-assisted failing canine circulation

  • Ofer Barnea
  • Thomas W. Moore
  • Dov Jaron


A model of the cardiovascular system is presented. The model includes representations of the left and right ventricles, a nonlinear multielement model of the aorta and its main branches, and lumped models of the systemic veins and the pulmonary circulation. A simulation of the intra-aortic balloon pump and representations of physiological compensatory mechanisms are also incorporated in the model. Parameters of the left ventricular model were set to simulate either the normal or failing canine circulation. Pressure and flow waveforms throughout the circulation as well as ventricular pressure and volume were calculated for the normal, failing, and assisted failing circulation. Cardiac oxygen supply and consumption were calculated from the model. They were used as direct indices of cardiac energy supply and utilization to assess the effects of cardiac assistance.


Model simulation Cardiovascular Cardiac assist Intra-aortic balloon Energy balance 



vessel cross-sectional area atm mmHg


ventricular pressure-volume ratio


maximum value ofE


normalizedE function


vessel wall elastance


blood pressure


unperturbed mean aortic root pressure


mean aortic root pressure


intramyocardial pressure


left ventricular pressure


pressure across aortic valve


systemic venous blood pressure


pressure-volume area


transmural pressure




left ventricular flow


net flow into a vessel segment


flow into aortic valve leaflets


radius of a balloon segment


radius of a vessel segment


total coronary flow per beat


time of end diastole


time of end systole


time whenE equalsEmax


normalized time


end diastolic ventricular pressure


oxygen availability per beat


oxygen consumption per beat


venous volume shift


aortic valve volume


blood viscosity


blood density


time constant


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Copyright information

© Pergamon Press plc 1990

Authors and Affiliations

  • Ofer Barnea
    • 1
  • Thomas W. Moore
    • 2
  • Dov Jaron
    • 2
  1. 1.Biomedical Engineering Program Department of Interdisciplinary Studies School of EngineeringTel Aviv UniversityTel AvivIsrael
  2. 2.Biomedical Engineering and Science InstituteDrexel UniversityPhiladelphia

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