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Bone metastasis from colorectal cancer in autopsy cases

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The incidence of bone metastasis from colorectal cancer is reported to be 10.7% in autopsy cases. However, the characteristics of the primary cancers, as well as the patterns of bone metastasis, remain unclear. We analyzed the clinical and autopsy records of 118 patients with primary colorectal cancer treated either surgically or conservatively and eventually autopsied between 1970 and 1987 at Toranomon Hospital in Tokyo. Bone metastasis was detected in 23.7% (28/118). The average age of patients with bone metastasis was lower than that in patients without bone metastasis (P<0.02). Cancers to the rectum and cecum were accompanied by bone metastasis more frequently than cancers of other portions of the colon. Signet-ring cell carcinoma showed a high incidence of bone metastasis (P=0.041). Bone metastasis from colorectal cancer was associated with liver or lung metastases (P<0.0001). These results indicated that bone metastasis from colorectal cancer is not as infrequent as previously described.

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Katoh, M., Unakami, M., Hara, M. et al. Bone metastasis from colorectal cancer in autopsy cases. J Gastroenterol 30, 615–618 (1995).

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