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A comparison of two prostaglandin analogues (enprostil vs misoprostol) in the treatment of acute duodenal ulcer disease

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Abstract

We conducted a clinical trial to compare the efficacy and safety profile of two prostaglandin analogues, enprostil (35 μg twice daily) and misoprostol (200 μg four times daily) in the treatment of acute duodenal ulcers in 214 patients. The two agents healed approximately 80% and in excess of 90% of duodenal ulcers after 4 and 6 weeks' therapy, respectively. There was a significantly lower ulcer healing rate in both treatment groups in smokers compared with nonsmokers (P<0.05). However, daytime and nighttime ulcer pain relief was achieved in fewer than 50% of patients by either agent. Diarrhea, which occurred in more than 40% of patients, was the predominant side effect, and occurred mainly during the first 2 weeks of therapy with either agent. Nevertheless, this side effect was mild and self-limiting in the majority of patients. Both agents were found to be safe and well tolerated by the majority of patients. We conclude that these prostaglandin analogues are safe and effective duodenal ulcer healing agents. Furthermore, there was very little difference between enprostil and misoprostol. The limiting factors, however, for their routine use as ulcer healing agents are their low efficacy with regard to ulcer pain relief and the high incidence of diarrhea.

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  1. Department of Medicine, University of Hong Kong, Queen Mary Hapital, Room 302, New Clinical Building, Pokfulam, Hong Kong

    C. K. Ching & S. K. Lam

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  1. C. K. Ching
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  2. S. K. Lam
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Ching, C.K., Lam, S.K. A comparison of two prostaglandin analogues (enprostil vs misoprostol) in the treatment of acute duodenal ulcer disease. J Gastroenterol 30, 607–614 (1995). https://doi.org/10.1007/BF02367786

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  • DOI: https://doi.org/10.1007/BF02367786

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