Abstract
To study bone involvement in primary biliary cirrhosis (PBC), we used dual-energy X-ray absorptiometry to measure bone mineral density (BMD) in Japanese women with PBC and with cirhosis of the liver. In both groups, in each decade up to 60 years of age, the mean BMD of the lumbar spine was not significantly different from that in healthy Japanese women; however, in patients aged 60 years or more, the level was significantly lower both in the patients with PBC (P<0.001) and in those with cirrhosis of the liver (P<0.01). Patients with PBC were also examined by single-photon absorptiometry. The BMD of the radius in the patients with PBC was less changed than that of the lumbar vertebrae; thus, the bone changes in PBC seem to be greater in spongy than in cortical bone.
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Atkinson M, Nordin BEC, Sherlock S. Malabsorption and bone disease in prolonged obstructive jaundice. Q J Med 1956;25: 299–312.
Long RG, Meinhard E, Skinner RK, et al. Clinical, biochemical, and histological studies of osteomalacia osteoporosis, and parathyroid function in chronic liver disease. Gut 1978;19:85–90.
LeBlanc AD, Evans HJ, Marsh C, et al. Precision of dual photon absorptiometry measurements. J Nucl Med 1986;27: 1362–1365.
Cullum ID, Ell PJ, Ryder JP. X-ray dual-photon absorptiometry: A new method for the measurement of bone density. Br J Radiol 1989;62:587–592.
Mazess RB, Collick B, Trempe J, et al. Performance evaluation of a dual-energy X-ray bone densitometer. Calcif Tissue Int 1989;44:228–232.
Thorson LM, Wahner HW. single- and dual-photon absorptiometry techniques for bone mineral analysis. J Nucl Med Technol 1986;14:163–171.
Sorenson JA, Cameron JR. A reliable in vivo measurement of bone-mineral content. J Bone Joint Surg 1967;49:481–497.
Brown JP, Delmas PD, Malaval L, et al. Serum bone Gla-protein: A specific marker for bone formation in postmenopausal osteoporosis. Lancet 1984;I:1091–1093.
Kushida K, Inoue T, Sumi Y, et al. Osteoporosis: Bone mineral measurement using DEXA. Jpn J Clin Med 1990;48:2845–2850.
Kato Y, Epstein O, Dick R, Sherlock S. Radiological patterns of cortical bone modeling in women with chronic liver disease. Clin Radiol 1913;33:313–317.
Leevy CM, Thompson A, Baker H. Vitamins and liver injury. Am J Clin Nutr 1970;23:493–499.
Kehayoglou AK, Holdsworth CD, Agnew JE, et al. Bone disease and calcium absorption in primary biliary cirrhosis, with special reference to vitamin D therapy. Lancet 1968;I:715–719.
Kanda T, Otsuki M, Hayashi Y, et al. Clinical and biochemical studies of osteopenia in liver cirrhosis. Jpn J Gastroenterol 1988;85:1088–1094.
Nakano A, Kanda T, Miyamoto T, et al. A study of osteopenia in liver cirrhosis by dual energy X-ray absorptiometry (DXA). Jpn J Gastroenterol 1993;90:1689–1694.
Herlong HF, Recker RR, Maddrey WC. Bone disease in primary biliary cirrhosis: Histologic features and response to 25-hydroxyvitamin D. Gastroenterology 1982;83:103–108.
Compston JE, Crowe JP, Wells IP, et al. Vitamin D prophylaxis and osteomalacia in chronic cholestatic liver disease. Dig Dis Sci 1980;25:28–32.
Danielsson A, Lorentzon R, Larsson S-E. Intestinal absorption and 25-hydroxylation of vitamin D in patients with primary biliary cirrhosis. Scand J Gastroenterol 1982;17:349–355.
Cuthbert JA, Park CYC, Zerwekh JE, et al. Bone disease in primary biliary cirrhosis: Increased bone resorption and turnover in the absence of osteoporosis or osteomalacia. Hepatology 1984;4:1–8.
Kato Y, Hattori N, Epstein O, Sherlock. Bone in primary biliary cirrhosis. Acta Hepatol Jpn 1983;24:31–34.
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Shiomi, S., Kuroki, T., Masaki, K. et al. Osteopenia in primary biliary cirrhosis and cirrhosis of the liver in women, evaluated by dual-energy X-ray absorptiometry. J Gastroenterol 29, 605–609 (1994). https://doi.org/10.1007/BF02365443
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DOI: https://doi.org/10.1007/BF02365443