Annals of Biomedical Engineering

, Volume 9, Issue 5–6, pp 593–604 | Cite as

Aerosol deposition and clearance in the human upper airways

  • David L. Swift
Respiratory Particle Transport

Abstract

The human upper respiratory tract, defined here as the airways above the trachea, is the portal of entry for airborne particles. Whether inhaled particles reach the bronchial or alveolated airways or are deposited in the upper airways (nasal or oral passage) depends upon a number of factors which are discussed in this paper. These factors can be divided into two groups: those which relate to the air flow properties and those which relate to the particles. If these factors are known to a sufficient degree, the regional deposition efficiency of the inhaled particles can be estimated. Particles once deposited in the upper airway are cleared by one of several mechanisms depending on the type of particle, site of deposition and functional state of the airway surface. The clearance processes and their importance for various particles are discussed.

Keywords

Respiratory Tract Functional State Flow Property Deposition Efficiency Airborne Particle 

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References

  1. 1.
    Bell, K.S. Aerosol deposition in models of a human lung bifurcation. Doctoral thesis. California Institute of Technology, 1974.Google Scholar
  2. 2.
    Fry, F.A. and A. Black, Regional deposition and clearance of particles in the human nose.J. Aerosol Sci. 4:113–124, 1973.Google Scholar
  3. 3.
    Harris, R.L. and D.A. Fraser, A model for deposition of fibers in the human respiratory tract.Am. Ind. Hyg. J. 37:73–89, 1976.Google Scholar
  4. 4.
    Heyder, J. and G. Rudolph, Deposition of aerosol particles in the human nose.Inhaled Particles IV, edited by W.H. Walton, Oxford: Pergamon Press, 1977, pp. 107–126.Google Scholar
  5. 5.
    Hounam, R.F., Black, A. and M. Walsh, Deposition of aerosol particles in the nasopharyngeal region of the human respiratory tract,Inhaled Particles III, Vol. 1, edited by W.H. Walton, London: Gresham Press, 1971, pp. 71–80.Google Scholar
  6. 6.
    Landahl, H.D. On the removal of airborne droplets by the human respiratory tract. The nasal passages.Bull. Math. Biophys. 12:161–169, 1950.Google Scholar
  7. 7.
    Masing, H. Exp. Examination on the flow course in the nose model.Arch. Klim. Exp. Ohr. Nas. Kehik. Heilk. 189:371–381, 1967.Google Scholar
  8. 8.
    Pattle, R.E. Retention of gases and particles in the human nose,Inhaled Particles and Vapors, edited by C.N. Davies. Oxford: Pergamon Press, 1961, pp. 302–311.Google Scholar
  9. 9.
    Proctor, D.F. Physiologic basis of voice training.Ann. N.Y. Acad. Sci. 155:208–228, 1968.Google Scholar
  10. 10.
    Proctor, D.F., Anderson, I. and G. Lundqvist, G. Nasal mucociliary functions in humans,Respiratory Defense Mechanisms Vol. 1, edited by J. Brain, D.F. Proctor, and L. Reid. New York: Marcel Dekker, 1976, pp. 63–93.Google Scholar
  11. 11.
    Proctor, D.F. and D.L. Swift, The nose-a defense against the atmospheric environment.Inhaled Particles III, Vol. I, edited by W.H. Walton, London: Gresham Press, 1971, pp. 50–70.Google Scholar
  12. 12.
    Proetz, A.W. Air currents in the upper respiratory tract and their clinical significance.Ann. Otol. 60:439–467, 1951.Google Scholar
  13. 13.
    Scott, W.R., Taulbee, D.B. and C.P. Yu. Theoretical studies of nasal deposition,Bull Math. Biol. 40:581–683, 1978.CrossRefPubMedGoogle Scholar
  14. 14.
    Swift, D.L., and D.F. Proctor, Access of air to the respiratory tract.Respiratory Defense Mechanisms, Vol. I, edited by J. Brain, D.F. Proctor, and L. Reid. New York: Marcel Dekker, 1976, pp. 63–93.Google Scholar
  15. 15.
    Swift, D.L., Shanty, F. and J.T. O'Neill, Human respiratory tract deposition of nuclei particles and health implications:Airborne Radioactivity. LaGrange, Ill: American Nuclear Society, 1977, pp. 183–189.Google Scholar

Copyright information

© Pergamon Press Ltd. 1982

Authors and Affiliations

  • David L. Swift
    • 1
  1. 1.School of Hygiene and Public HealthJohns Hopkins UniversityBaltimore

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