Annals of Biomedical Engineering

, Volume 8, Issue 2, pp 143–158 | Cite as

Possible optimization of respiratory controller sensitivity

  • Guy S. Longobardo
  • Neil S. Cherniack
  • Aniko Damokosh-Giordano


The effect of respiratory controller gain on the speed of correction of disturbances in CO2 balance, and the energy used by the respiratory muscles during the correction period is explored using a mathematical model. As controller sensitivity is increased, CO2 balance is more rapidly restored, but there is a greater expenditure of energy in breathing. The relationship between speed of correction and energy expenditure rises to a maximum value near usual values for controller sensitivity to CO2 in normal human adults. With less efficient respiratory muscles or with higher resting levels of PCO2, maximum values for the ratio of speed to energy consumption occur at decreased levels of controller sensitivity. Increased cardiac output and functioning central and peripheral CO2 chemoreceptors improve speed of response without proportionate rises in energy use.


Mathematical Model Energy Consumption Cardiac Output Respiratory Muscle Human Adult 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Pergamon Press Ltd. 1980

Authors and Affiliations

  • Guy S. Longobardo
    • 1
  • Neil S. Cherniack
    • 1
  • Aniko Damokosh-Giordano
    • 1
  1. 1.Department of MedicineCase Western Reserve UniversityCleveland

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