Abstract
A system has been developed for measuring and relating in a non-beating isolated canine left ventricle dynamic changes in chamber pressure, volume, diameter, regional segment length, and wall thickness. The measurement system consists of a pulsatile blood pump whose stroke-volume and frequency can be adjusted selectively. The external pump system is used as a primary means for controlling instantaneous intraventricular volume. The relationship between left ventricular volume change, intraventricular pressure, minor axis diameter, and regional dimensions were studied as a function of pump rate.In addition to the basic constitutive properties, this system provided the means for measuring and comparing regional and global pressurestrain relationship including the effect of strain rate and its relationship to viscoelastic myocardial muscle model. The dynamic relationship between global dimensions and regional dimensions, circumferential segment length, and wall thickness were also investigated. The instantaneous relationship between intraventricular pressure resulting from periodic oscillations of chamber volume, including minor equator diameter, wall thickness, and regional segment dimensions were plotted and fitted to an exponential pressure-strain model, assuming a quasi-static large deformation. The observed difference between global and regional pressure-dimension strain stiffness coefficients can be attributed in part to basic constitutive and geometric considerations and not necessarily to the complex anisotropic or heterogeneous nature of cardiac muscle properties. This methodology provides indices which appropriately characterize the regional and global left ventricular chamber deformation and stiffness.
Similar content being viewed by others
References
Glantz, F.A., Parmley, W.W. Factors which effect diastolic pressure-volume curve. Circ. Res., 42:171–179, 1978.
Guntheroth, W.G. Changes in left ventricular wall thickness during cardiac cycle. J. of App. Phys., 36:308–312, 1974.
Hill, R.C., Kleinman, L.H., Chitwood, W.R., Jr., Wechsler, A.S.. Segmental mid-wall myocardial dimensions in man recorded by sonomicrometry. J. Thor. Cardiovasc. Surg., 76:235–243, 1978.
Horowitz, L.D., Bishop, W.S., Stone, H.L., Stegall, H.F. Continuous measurement of internal left ventricular diameter. J. Appl. Phys., 24:738–740, 1968.
Kresh, J.Y., Cobanoglu, M.A., Brockman, S.K. The intramyocardial pressure: a parameter of heart contractility. Heart Transplantation, 4:241–246, 1985.
Mirsky, I., Cohn, P., Levine, J., Golan, R., Herman, M.V., Kreulen, P.H., Sonneblick, E.H. An assessment of left ventricular wall stiffness in primary myocardial disease and coronary artery disease. Circ. Res., 50:128–136, 1974.
Mirsky, I., Parmley, W.W. Assessment of passive elastic stiffness in the isolated heart muscle and the intact heart. Circ. Res., 33:233–243, 1973.
Sasayama, S., Franklin D., Ross, J., Kemper, W., McKown, D. Dynamic changes in left ventricular wall thickness and their use in analyzing cardiac function in the conscious dog. Am. J. Cardiol., 38:870–878 1976.
Streeter D.D., Jr., Spotnitz, H.N., Patel D.P., Ross, J., Jr., Sonneblick, E.H. Fiber orientation in a canine left ventricle during diastole and systole. Circ. Res., 26:339–347, 1969.
Swain, J.L., Morris, K., Bruno, F.P., and Cobb, F.R.. Comparison of multigated radionuclide angiography with ultrasonic sonomicrometry over a wide range of ventricular function in the conscious dog. Am. J. Cardiol., 46:976–982, 1980.
Theroux, P., Ross, J., Franklin, D., Kemper, W., Sasayama, S. Regional myocardial function in the conscious dog during acute coronary occlusion and response to morphine, propranolol, nitroglycerin, and lidocane. Circ., 53:302–314, 1976.
Weber, K.T., Janicki, J.S. The heart as a muscle-pump system and the concept of heart failure. Am. Heart J., 98:371–384, 1979.
Suga, H., Sagawa, K. Assessment of absolute volume from diameter of the intact canine left ventricular cavity. J. Appl. Physiol., 36:496–499, 1974.
Olsen, C.O., Rankin, J.S., Arentzen, C.E., Ring, W.S., McHale, P.A., Anderson, R.W. The deformational characteristics of the left ventricle in the conscious dog. Circ. Res., 49:843–855, 1981.
Rankin, J.S., Arentzen, C.E., McHale, P.A., Ling, D., Anderson, R. Viscoelastic properties of the diastolic left ventricle in the conscious dog. Circ. Res., 41:37–45, 1977.
Kresh, J.Y., Brockman, S.K. An interactive microcomputer-based graphics system for analysis of cardiodynamic function. Comput. Biol. Med. 14:419–427, 1984.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kresh, J.Y., Brockman, S.K. A model-based system for assessing ventricular chamber pressure-volume-dimension relationship: Regional and global deformation. Ann Biomed Eng 14, 15–33 (1986). https://doi.org/10.1007/BF02364646
Issue Date:
DOI: https://doi.org/10.1007/BF02364646