Annals of Biomedical Engineering

, Volume 7, Issue 1, pp 45–57 | Cite as

Modeling and parameter estimation of yeast size distribution dynamics

  • Paul J. Palatt
  • Gerald M. Saidel
Article

Abstract

The dynamic behavior of a batch culture of yeast with a rate-limiting nutrient was analyzed by examining the cell number density, cell size distribution, and concentration of a rate-limiting nutrient. The particular strain of S. cerevisiae studied grows only when the medium contains L-tryptophan. The cell number, volume distribution, and external L-tryptophan concentration were measured at successive times in the development of the culture. A mathematical model was developed to simulate the experimental data and provide a framework for understanding the dynamics of the cell growth and division in terms of cellular events. A nonlinear optimization procedure was specially adapted to estimate model parameters.

Keywords

Experimental Data Mathematical Model Cell Growth Parameter Estimation Cell Size 

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Copyright information

© Pergamon Press Ltd. 1979

Authors and Affiliations

  • Paul J. Palatt
    • 1
  • Gerald M. Saidel
    • 1
  1. 1.Department of Biomedical EngineeringCase Western Reserve UniversityCleveland

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