Annals of Biomedical Engineering

, Volume 7, Issue 1, pp 45–57 | Cite as

Modeling and parameter estimation of yeast size distribution dynamics

  • Paul J. Palatt
  • Gerald M. Saidel


The dynamic behavior of a batch culture of yeast with a rate-limiting nutrient was analyzed by examining the cell number density, cell size distribution, and concentration of a rate-limiting nutrient. The particular strain of S. cerevisiae studied grows only when the medium contains L-tryptophan. The cell number, volume distribution, and external L-tryptophan concentration were measured at successive times in the development of the culture. A mathematical model was developed to simulate the experimental data and provide a framework for understanding the dynamics of the cell growth and division in terms of cellular events. A nonlinear optimization procedure was specially adapted to estimate model parameters.


Experimental Data Mathematical Model Cell Growth Parameter Estimation Cell Size 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Pergamon Press Ltd. 1979

Authors and Affiliations

  • Paul J. Palatt
    • 1
  • Gerald M. Saidel
    • 1
  1. 1.Department of Biomedical EngineeringCase Western Reserve UniversityCleveland

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