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Annals of Biomedical Engineering

, Volume 7, Issue 3–4, pp 329–343 | Cite as

Controlled release micropump for insulin administration

  • Michael V. Sefton
  • Harris M. Lusher
  • Selwyn R. Firth
  • Mikhel U. Waher
Article

Abstract

A novel controlled release micropump has been developed for the administration of insulin at both basal and postprandial delivery rates. Transport through a hydrophilic polyurethane foam (Hypol) provides the basal delivery, while repeated compression of the foam by the core of a solenoid augments the delivery as needed. The pump contains only one moving part, and is without any valves. It consumes power only during the postprandial delivery phase, which is a small fraction of the total delivery. Using both amaranth and insulin, the effects of pressure drop, foam length, and power input on the performance of the pump were evaluated. Although the degree of augmentation increased with decreasing basal delivery rate suggesting a stroke volume independent of basal rate, calculations based on a simple model showed that the stroke volume increased with increasing basal rate. The successful development of this delivery system will enable biomedical investigators to evaluate the relationship between metabolic regulation of glucose level and the genesis of diabetic sequelae and to assess the value of this pump in a new form of insulin therapy.

Keywords

Foam Pressure Drop Polyurethane Stroke Volume Power Input 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Table of nomenclature

A

membrane area

Cf

feed concentration

C, Ct

concentration in downstream reservoir at time t

Co

concentration in downstream reservoir at t=0

f

frequency of compression

K

Darcy's law permeability

L

membrane length or thickness

ΔP

pressure difference across membrane

Q

volumetric delivery rate

Qo

basal delivery rate

R

solenoid coil resistance

t

time

Vs

stroke volume

Vo

volume of solute free solvent added to downstream reseroir prior to initiation of experiment

porosity

μ

viscosity

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Copyright information

© Pergamon Press Ltd. 1979

Authors and Affiliations

  • Michael V. Sefton
    • 1
  • Harris M. Lusher
    • 1
  • Selwyn R. Firth
    • 1
  • Mikhel U. Waher
    • 1
  1. 1.Department of Chemical Engineering and Applied ChemistryUniversity of TorontoTorontoCanada

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