Annals of Biomedical Engineering

, Volume 15, Issue 5, pp 503–519 | Cite as

Through the microcirculatory maze with machete, molecule, and minicomputer (1986 Alza lecture)

  • James B. Bassingthwaighte


This is a personal historical essay on meanderings through the jungle of the microcirculatory swamp. Because one pretends that the wandering was purposefully exploratory, a few guideposts are placed at positions where one could discern blazemarks from earlier wanderers, and the path cut a little wider along some of the routes that may be enjoyed by investigators wanting to put their blazes along more distant paths. Naturally, one starts by coming up the broad rivers, the branching into the little streams. Each of us chooses to seek a different “mother lode,” up a different stream.


Intravascular transport Indicator dilution Organ blood flow Capillary permeability Pores membrane transporters Substrate metabolism Tracer kinetics Heterogeneity Blood-tissue exchange models 


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© Pergamon Journals Ltd 1987

Authors and Affiliations

  • James B. Bassingthwaighte
    • 1
  1. 1.Center for Bioengineering, WD-12University of WashingtonSeattle

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