Annals of Biomedical Engineering

, Volume 8, Issue 4–6, pp 391–404 | Cite as

The development of recognition of component significance in closed-loop cardiovascular control

  • Abraham Noordergraaf
  • Julius Melbin
Cardiovascular Control

Abstract

The development of physical or mathematical models offers potentially powerful instruments for understanding interactive mechanics of the circulatory system. Coupled with computer technology, the resultant scientific armamentarium held promise of rapid solutions to complex problems. Expectations have not been fulfilled for several reasons, which are discussed. Lack of information, necessary to achieve realistic model responses, often constrains their applicability. Since complete information, required for all components, may not be available, the importance of representing specific task-significant components is explored. The successful use of this approach is illustrated.

Keywords

Mathematical Model Circulatory System Complex Problem Component Significance Model Response 

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Copyright information

© Pergamon Press Ltd. 1981

Authors and Affiliations

  • Abraham Noordergraaf
    • 1
    • 2
  • Julius Melbin
    • 1
    • 2
  1. 1.Department of BioengineeringUniversity of PennsylvaniaPhiladelphia
  2. 2.Department of Animal BiologyUniversity of PennsylvaniaPhiladelphia

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