Intercalated discs as a cause for discontinuous propagation in cardiac muscle: A theoretical simulation
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A theoretical model of a cardiac muscle fiber (strand) based on core conductor principles and which includes a periodic intercalated disc structure has been developed. The model allows for examination of the mechanism of electrical propagation in cardiac muscle on a microscopic cell-to-cell level. The results of the model simulations demonstrate the discontinuous nature of electrical propagation in cardiac muscle and the inability of classical continuous cable theory to adequately describe propagation phenomena in cardiac muscle.
KeywordsCardiac electrophysiology Cable models Intercalated discs Cell-to-cell conduction Discontinuous electrical propagation
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- 2.Beeler, G.W. and H. Reuter. Reconstruction of the action potential of ventricular myocardial fibres.J. Physiol. London 286:177–210, 1977.Google Scholar
- 5.Crank, J. and P. Nicolson. A practical method for numerical evaluation of solutions of partial differential equations of the heat conduction type.Proc. Cambridge Philos. Soc. 43:50–77, 1947.Google Scholar
- 6.Draper, M.H. and M. Mya-Tu. A comparison of the conduction velocity of cardiac tissue of various animals.Q. J. Exp. Physiol. 44:91–109, 1959.Google Scholar
- 10.Hodgkin, A.L. and W.A.H. Rushton. The electrical constants of a crustacean nerve fiber.Proc. R. Soc. London, Ser. B 133:444–508, 1946.Google Scholar
- 12.Lowenstein, W.R. Junctional intercellular communication: The cell-to-cell membrane channel.Physiol. Rev. 61:829–913, 1981.Google Scholar
- 15.Page, E. and L.P. McAllister. Studies on the intercalated discs of rat ventricular myocardial cells.J. Ultra. Res. 43:388–411, 1973.Google Scholar
- 16.Page, E. and Y. Shibata. Permeable junctions between cardiac cells.Ann. Rev. Physiol. 43:431–442, 1981.Google Scholar
- 19.Sjostrand, F.S. and E. Anderson-Cedergren. Intercalated discs of heart muscle. InThe Structure and Function of Muscle, Vol. 1, edited by G. Bourne. New York: Academic Press, 1960, pp. 421–445.Google Scholar
- 21.Spira, A.W. The nexus in the intercalated disc of the canine heart: Quantitative data for the estimation of its resistance.J. Ultra. Res. 34:409–425, 1971.Google Scholar
- 24.Woodbury, J.W. and W.E. Crill. On the problem of impulse conduction in the atrium. InNervous Inhibition, edited by L. Florey. New York: Plenum Press, 1961, pp. 24–35.Google Scholar