Neuroscience and Behavioral Physiology

, Volume 24, Issue 6, pp 479–482 | Cite as

Participation of opiate δ-receptors in immunomodulation

  • M. A. Cheido
  • G. V. Idova


The activation of the opiate δ-receptors by the highly specific agonist DSLET evokes an immunoinhibitory effect in CBA mice which disappears with preliminary blockade of S2 serotonin receptors by cyproheptadine. The blockade of δ-receptors by the antagonist ICI 174 864 leads to stimulation of the immune response, which is tested on the basis of the number of rosette-forming cells. Neither stimulation nor suppression of immunogenesis are manifested in animals with a transsected hypophyseal stalk; this suggests the central action of the opioids. The increase in the immune response obtained with the administration of ICI 174 864 is associated with the dopaminergic system, since it is prevented by haloperidol. It was demonstrated that the thymus participates in the immune-stimulating influence of ICI 174 864.


Immune Response Serotonin Haloperidol Central Action Dopaminergic System 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Publishing Corporation 1994

Authors and Affiliations

  • M. A. Cheido
    • 1
  • G. V. Idova
    • 1
  1. 1.Department of the Physiology of Man and Animals, State UniversitySamara

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