Skip to main content
SpringerLink
Log in

Influence of perfusates of tetanized donor slices on the induction of long-term potentiation in recipient slices

  • Published:
Neuroscience and Behavioral Physiology Aims and scope Submit manuscript

Abstract

A perfusate collected from donor slices of the olfactory cortex of the brain of rats during tetanization of the lateral olfactory tract (100 imp/sec, 30 sec) induced prolonged changes in the amplitudes of various components of the focal potentials (FP) in recipient slices. When the perfusates are divided in relation to the reactions arising in the donor slices into three types, “potentiated,” “depressive,” and “nonpotentiated,” the reactions of the recipient slices prove to be diverse. The potentiated perfusate induced the development of depression. The depressive induced potentiation. The reactions of the recipient slices to the nonpotentiated perfusate were indeterminate. The data obtained suggest the secretion of active substances during the electrical tetanization of donor slices. These factors are capable of inducing reactions in the recipient slices which the donor slices had “experienced.”

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. A. A. Mokrushin and S. S. Musyashchikova, “The development of short-term habituation in surviving brain slices,”Fiziol. Zh. SSSR,74, No. 12, 1723–1730 (1988).

    CAS  PubMed  Google Scholar 

  2. A. A. Mokrushin and N. A. Emel'yanov, “Posttetanic and frequency potentiation in slices of the olfactory cortex of the brain of rats,”Fiziol. Zh. SSSR,76, No. 4, 425–429 (1990).

    CAS  PubMed  Google Scholar 

  3. V. I. Khichenko and O. G. Safronova, “The formation of long-term sensitization in a semi-intact preparation is facilitated in the hemolymph of the sensitized snail,” in:Simple Nervous Systems [in Russian], Moscow (1991), p. 35.

  4. C. Charrialt-Marlangue, L. Aniksztejn, M. P. Rosin, et al., “Release of proteins during long-term potentiation in the hippocampus of anesthetized rat,”Neurosci. Lett.,91, No. 3, 308–314 (1988).

    Google Scholar 

  5. S. A. Deadwyler, T. Dunwidde, and G. Lynch, “A critical level of protein synthesis is required for long-term potentiation,”Synapse,1, No. 1, 90–95 (1987).

    CAS  PubMed  Google Scholar 

  6. G. J. Duffy, T. J. Teyler, and V. E. Shashoua, “Long-term potentiation in the hippocampal slices: evidence for stimulated secretion of newly synthesized proteins,”Science,212, No. 4449, 1148–1151 (1981).

    CAS  PubMed  Google Scholar 

  7. M. S. Fazeli, M. L. Errington, A. C. Dolphin, et al., “Long-term potentiation in rat dentate gyrus of the anesthetized rat is accompanied by an increase in protein efflux into push-pull cannula perfusates,”Brain Res.,473, No. 1, 51–59 (1988).

    CAS  PubMed  Google Scholar 

  8. S. Otani, C. J. Marshall, W. P. Tate, et al., “Maintenance of long-term potentiation in rat dentate gyrus required protein synthesis but not messenger RNA synthesis immediately post-tetanization,”Neurosci.,28, No. 2, 519–526 (1989).

    CAS  Google Scholar 

  9. P. K. Stanton and J. M. Sarvey, “Blockade of long-term potentiation in rat hippocampal CA1 region by inhibitory of protein synthesis,”J. Neurosci.,2, No. 3, 3080–3088 (1984).

    Google Scholar 

  10. B. R. Sastry, S. S. Chirwa, P. B. Y. May, et al., “Are nerve growth factor involved in long-term synaptic potentiation in the hippocampus and spatial memory?” in.Synaptic Plasticity in the Hippocampus, H. Hass and G. Buzsaki (eds.), Springer, Heidelberg (1988), pp. 102–105.

    Google Scholar 

  11. B. R. Sastry, S. S. Chirwa, P. B. Y. May, et al., “Substances released during tetanic stimulation of rabbit neocortex induce neurite growth in PC-12 cells and long-term potentiation in guinea-pig hippocampus,”Neurosci. Lett.,91, 101–105 (1988).

    Article  CAS  PubMed  Google Scholar 

  12. N. Uenishi, T. J. Shors, C. D. Finch, et al., “Increased synthesis of two polypeptides in area CA1 of the hippocampus in response to repetitive electrical stimulation,”Brain Res.,567, No. 2, 248–252 (1991).

    CAS  PubMed  Google Scholar 

  13. Z. Xie, W. Morishita, T. Kam, et al., “Studies on substances that induce long-term potentiation in guinea-pig hippocampal slices,”Neurosci.,43, No. 1, 11–20 (1991).

    CAS  Google Scholar 

Download references

Authors
  1. A. A. Mokrushin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. I. V. Karpova
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Laboratory of the Regulation of the Functions of Brain Neurons, I. P Pavlov Institute of Physiology, Russian Academy of Sciences, Saint Petersburg. Translated from Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 80, No. 3, pp. 8–12, March, 1994. Or

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mokrushin, A.A., Karpova, I.V. Influence of perfusates of tetanized donor slices on the induction of long-term potentiation in recipient slices. Neurosci Behav Physiol 25, 296–299 (1995). https://doi.org/10.1007/BF02360040

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02360040

Keywords

Search

Navigation