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Neuroscience and Behavioral Physiology

, Volume 24, Issue 5, pp 414–422 | Cite as

The features of the participation of the cholinergic mechanisms of the accumbens and caudate nuclei in the regulation of an instrumental defense reflex in dogs

  • K. B. Shapovalova
  • E. V. Pominova
Article

Abstract

The influence of microinjections of carbacholine (0.1, 0.05, and 1.0 μg) into the dorsal striatum (head of the caudate nucleus) and the ventral striatum (nucleus accumbens) on the motor components of the instrumental response and the criteria of execution of an instrumental task was studied in chronic experiments in eight dogs, based on a model of an instrumental defense reflex associated with the maintenance of a specific posture. The varied participation of the cholinoreactive structures of the caudate and accumbens nuclei in the regulation of the instrumental defense reflex was demonstrated in the dogs. Data were obtained indicating that the cholinoreactive system of the contralateral head of the caudate nucleus is structurally included in the regulation of the motor components of the instrumental response, of the main component of the reorganization of posture (the “disburdening” of the working extremity), and in the regulation of the tonic component of the voluntary movement and of its form. At the same time, the injection of carbacholine into the nucleus accumbens exerted, rather, a nonspecific activating influence on the motor systems. An improvement in attention to significant stimuli and the prolongation of the observed effects were also features of the activation of the cholinoreactive system of this nucleus. These changes took place in the case of both ipsi- and contralateral influences; this makes it possible to consider the inclusion mainly of sensory mechanisms in the realization of these influences.

Keywords

Nucleus Accumbens Caudate Nucleus Motor System Specific Posture Voluntary Movement 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    V. P. Petropavlovskii, “Methods for the formation of motoric conditioned reflexes,”Fiziol. Zh. SSSR,17, No. 2, 217–226 (1934).Google Scholar
  2. 2.
    K. B. Shapovalova,The Role of Cortical and Subcortical Structures in the Sensorimotor Integration [in Russian], Leningrad (1978).Google Scholar
  3. 3.
    K. B. Shapovalova, “Possible neurophysiological and neurochemical mechanisms of the participation of the striatum in the initiation and regulation of voluntary movement,”Fiziol. Zh. SSSR,71, No. 5, 537–553 (1985).PubMedGoogle Scholar
  4. 4.
    K. B. Shapovalova, “The cholinergic mechanism of the regulation by the neostriatum of conditioned reflex postural reorganization in dogs,”Fiziol. Zh. SSSR,74, No. 4, 478–489 (1988).Google Scholar
  5. 5.
    K. B. Shapovalova, “The neostriatum and the regulation of voluntary movement in the norm and pathology: facts and hypotheses,”Fiziologiya Cheloveka,15, No. 3, 78–92 (1989).Google Scholar
  6. 6.
    K. B. Shapovalova, A. I. Gorbachevskaya, and N. B. Saul'skaya, “The structural organization and neurochemical mechanisms of the participation of the nucleus accumbens in the interaction of the limbic and motor systems and in the regulation of motor behavior,”V. Vyssh. Nervn. Deyat.,42, No. 2, 226–276 (1992).Google Scholar
  7. 7.
    K. B. Shapovalova and E. V. Pominova “The participation of the cholinergic system of the nucleus accumbens in the differentiation of acoustic signals,”Zh. Vyssh. Nervn. Deyat.,42, No. 5, 919–929 (1992).Google Scholar
  8. 8.
    K. B. Shapovalova and E. V. Pominova, “The cholinoreactive system of the neostriatum and active avoidance behavior in a T-maze in rats,”Zh. Vyssh. Nervn Deyat.,43, No. 4, 800–807 (1993).Google Scholar
  9. 9.
    K. B. Shapovalova, I. V. Yakunin, and M. I. Boiko, “The participation of the head of the caudate nucleus of dogs in the mechanisms of conditioned reflex reorganization of posture,”Zh. Vyssh. Nervn. Deyat.,34, No. 4, 669–677 (1984).Google Scholar
  10. 10.
    A. F. Yakimovskii,The Participation of Dopamine- and Enkephalinergic Systems of the Caudate Nucleus in the Regulation of Conditioned Reflex Activity [in Russian], Leningrad (1984).Google Scholar
  11. 11.
    N. S. Austin and P. W. Kalivas, “The effect of cholinergic stimulation in the nucleus accumbens on locomotor behavior,”Brain Res.,441, No. 1/2, 209–214 (1988).PubMedGoogle Scholar
  12. 12.
    R. J. Beninger, “The role of dopamine in locomotor activity and learning,”Brain Res. Rev.,6, No. 2, 173–196 (1983).Google Scholar
  13. 13.
    R. B. Chronister, R. Sikes, J. Wood, and J. F. De France “The pattern of ventral tegmental afferents into the nucleus accumbens: An anterograde HRP analysis,”Neurosci. Lett.,17, No. 3, 231 (1980).PubMedGoogle Scholar
  14. 14.
    H. C. Fibiger, “The organization and some projections of cholinergic neurons of the mammalian forebrain,”Brain Res.,4, No. 3, 327–388 (1982).Google Scholar
  15. 15.
    M. Herkenham, E. S. Moon, and J. Stuart, “Cell clusters in the nucleus accumbens of the rat and mosaic relationship of opiate receptors, acetylcholinesterase and subcortical afferent terminals,”Neuroscience,11, No. 3, 561–593 (1984).PubMedGoogle Scholar
  16. 16.
    B. Johnels and G. Steg, “The corpus striatum and the regulation of posture and locomotion,”Neurosci. Lett.,19, No. 5, 339 (1980).Google Scholar
  17. 17.
    P. H. Kelley, P. W. Sevior, and S. D. Iwersen, “Amphetamine and apomorphine responses in the rat following 6-OHDA lesion of the nucleus accumbens septi and corpus striatum,”Brian Res.,94, No. 3, 507–522 (1975).Google Scholar
  18. 18.
    H. Kimura, P. McGeer, J. Peng, and E. McGeer, “The central cholinergic system studied by choline acetyltransferase immunohistochemistr in the rat,”J. Comp. Neurol.,200, No. 2, 151–201 (1981).PubMedGoogle Scholar
  19. 19.
    R. Lim, Ch. Liu, and R. A. Moffit,A Stereotaxic Atlas of the Dogs Brain, Illinois (1960).Google Scholar
  20. 20.
    P. McGeer, E. McGeer, and V. Innanen, “Dendro-axonic transmission. I. Evidence from receptor binding of dopaminergic and cholinergic agents,”Brain Res.,169, No. 3, 433–441 (1979).PubMedGoogle Scholar
  21. 21.
    R. Prado-Alcala, M. Fernandez-Samblacat, and M. Solodkin-Herrera, “Injections of atropine into caudate nucleus impair the acquisition and maintenance of passive avoidance,”Pharmacol. Biochem. Behav.,22, No. 2, 243–247 (1985).PubMedGoogle Scholar
  22. 22.
    C. J. Pycock and O. T. Phillipson, “A neuroanatomical and neuropharmacological analysis of basal ganglia output,” in:Handbook of Psychopharmacology, Vol. 18, New York: London (1984), pp. 191–278.Google Scholar
  23. 23.
    E. M. Stricker and M. J. Zigmond, “Brain monoamines, homeostasis and adaptive behavior,” in:Handbook of Physiology. IV. The Nervous System, Bethesda (1986), pp. 677–700.Google Scholar

Copyright information

© Plenum Publishing Corporation 1994

Authors and Affiliations

  • K. B. Shapovalova
    • 1
  • E. V. Pominova
    • 1
  1. 1.Laboratory of Physiology of Higher Nervous Activity, I. P. Pavlov Institute of PhysiologyRussian Academy of SciencesSaint Petersburg

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