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The correlation between changes in synaptic efficiency and cellular excitability during the development of a conditioned reflex analog

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Abstract

The calculation of the coefficient of correlation between changes in the direct (D) and monosynaptic (I) components of the pyramidal tract (PT) response made it possible to establish the presence of a positive linear association between conditioned reflex changes in synaptic efficiency and the shifts in cellular excitability observed at the same time. The coincidence of the maximal strength of this association with the greatest increase in cellular excitability which is dependant on the activation of motivatiogenic structures points to the role of these subcortical structures in the launching of intracellular reactions which leads to the formation of the overall molecular substrate which underlies interaction of membrane and synaptic mechanisms. The preceding of the greatest enhancement of synaptic efficiency by the maximal manifestation of the interaction attests to the contribution of this process to the manifestation of the principal mechanism of the conditioned reflex (CR).

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Authors and Affiliations

  1. Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow

    R. G. Kozhedub

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  1. R. G. Kozhedub
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Translated from Zhurnal Vysshei Nervnoi Deyatel'nosti imeni I. P. Pavlova, Vol. 43, No. 3, pp. 507–513, May–June, 1993.

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Kozhedub, R.G. The correlation between changes in synaptic efficiency and cellular excitability during the development of a conditioned reflex analog. Neurosci Behav Physiol 24, 381–385 (1994). https://doi.org/10.1007/BF02359788

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  • DOI: https://doi.org/10.1007/BF02359788

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