Skip to main content
SpringerLink
Log in

Food-procuring behavior of rats under the conditions of chronic activation and blockade of the neostriatal dopaminergic system

  • Published:
Neuroscience and Behavioral Physiology Aims and scope Submit manuscript

Abstract

Using the technique of intracerebral microinjections, the features of food-procuring behavior (the realization of a situational instrumental conditioned reflex in a Skinner box) were investigated in rats in experiments under the conditions of a pharmacological influence on the dopaminergic system of the neostriatum. Amphetamine in a dose of 15 and 45 μg and haloperidol in a dose of 5 mg were injected daily over the course of three weeks bilaterally into the rostral division of the neostriatum. A amphetamine dose of 15 μg was ineffective, but a increase in motor hyperactivity, a behavioral stereotypy, and a substantial acceleration of food-procuring movements were observed against the background of the injection of 45 μg of amphetamine. Stimulation of the dopaminergic system of the neostriatum qualitatively altered the behavioral strategy in animals with an initially low level of realization of the reflex; this fostered a stable activation of the instrumental skill enduring even after the cessation of the microinjections. Chronic blockade of dopamine receptors by haloperidol induced the reverse effect.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. O. B. Butenko, R. N. Kordzadze, and G. G. Barsegyan, “Influence of stimulation and blockade of the dopaminergic system on the choice behavioral strategy of rabbits in a shuttle box,”Byull. Éksp. Biol. Medits.,114, No. 12, 573 (1992).

    CAS  Google Scholar 

  2. E. A. Gromova,Emotional Memory and Its Mechanisms [in Russian], Moscow (1980).

  3. E. M. Zhukova, V. K. Spiridonov, and L. V. Loskutova, “The effects of the injection of 6-hydroxydopamine i regions of the nigrostriatal (A9) and mesolimbic (A10) dopaminergic systems on the development of an alimentary conditioned reaction in rats,”Zh. Vyssh. Nervn. Deyat.,37, No. 1, 88 (1987).

    CAS  Google Scholar 

  4. I. V. Karpova, “The content of dopamine, its metabolites, and GABA in the nigrostriatal system in rats with varied capacity for learning,”Zh. Vyssh. Nervn. Deyat.,42, No. 1, 161 (1992).

    CAS  Google Scholar 

  5. V. A. Otellin and É. B. Arashunyan,The Nigrostriatal System [in Russian], Moscow (1989).

  6. N. P. Shugalev, “The mediator systems of the brain and the mechanisms of the formation of extinctive inhibition,”Usp. Fiziol. Nauk,21, No. 3, 59 (1990).

    CAS  PubMed  Google Scholar 

  7. A. F. Yakimovskii, “The alimentary conditioned reflex in dogs during the pharmacological activation and blockade of the dopaminoreactive structures of the caudate nucleus,”Zh. Vyssh. Nervn. Deyat.,34, No. 2 345 (1984).

    Google Scholar 

  8. A. F. Yakimovskii, “A means of long-term local action on the neuromediator systems of the brain,”Fiziol. Zh. SSSR,74, No. 3, 745 (1988).

    Google Scholar 

  9. A. F. Yakimovskii and I. V. Karpova, “The influence of chronic activation and blockade of the dopamine- and enkephalinergic system of the neostriatum on conditioned reflex behavior and on dopamine metabolism in the nigrostriatal system,”Zh. Vyssh. Nervn. Deyat.,42, No. 5, 930 (1992).

    Google Scholar 

  10. A. F. Yakimovskii and N. B. Saul’skaya, “Change in synaptic release of catecholamines of the striatum of rats during repeated microinjections into it of amphetamine and haloperidol,”Fiziol. Zh. SSSR,77, No. 2, 43 (1992).

    Google Scholar 

  11. G. D. Carr and M. W. White, “Conditioned place preference from intraaccumbens but not intracaudate amphetamine injections,”Life Sci.,33, 2551 (1983).

    CAS  PubMed  Google Scholar 

  12. A. M. Graybield, “Neurotransmitters and neuromodulators in the basa ganglia,”Trends Neurosci.,13, 244 (1990).

    Google Scholar 

  13. S. Pradhan and S. Dutta, “Central cholinergic mechanism and behavior,”Intern. Rev. Neurol.,14, 173 (1971).

    CAS  Google Scholar 

  14. U. K. Rinne, J. O. Rinne, J. K. Rinne, and K. Laakso, “Chemical neurotransmission in the Parkinsonian brain,”Med. B Biol.,65, 75 (1987).

    CAS  Google Scholar 

  15. K. B. Shapalova and A. F. Yakimovski, “The role of motor and mesolimbic dopaminergic brain systems in the control of voluntary movements and posture adjustment in dogs,” in:Stance and Motion: Facts and Concepts, J. Masson, et al. (eds.), Plenum Press, New York-London (1988), p. 203.

    Google Scholar 

Download references

Authors
  1. A. F. Yakimovskii
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. V. Filatova
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, Saint Petersburg. Translated from Zhurnal Vysshei Nervnoi Deyatel’nosti imeni I. P. Pavlova, Vol. 44, No. 4-5, pp. 731–737, July–October, 1994.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yakimovskii, A.F., Filatova, E.V. Food-procuring behavior of rats under the conditions of chronic activation and blockade of the neostriatal dopaminergic system. Neurosci Behav Physiol 25, 427–432 (1995). https://doi.org/10.1007/BF02359600

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02359600

Keywords

Search

Navigation