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Influence of leukotrienes B4 and C4, 12-hydroxy-eicosatetraenoic acid, and erythro epimers of hepoxilin B3 on the plasticity of cholinoreceptors of neurons of the common snail

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Abstract

The influences of a number of acyclic eicosanoids which are formed from arachidonic acid under the influence of 5- and 12-lipoxygenases on the plasticity of cholinoreceptors of neurons of the common snail, which was assessed on the basis of the degree of frequency depression of the amplitude of the inward current induced by local application of acetylcholine to the soma, were investigated in identified RPa3 and LPa3 neurons of the common snail using the method of bielectrode recording of the potential on the membrane. The plasticity of the cholinoreceptors was enhanced by leukotrienes B4 and C4, and was not altered by 12(S)-hydroxy-(5Z, 8Z, 10E, 14Z)-eicosatetraenoic acid, or by the threo and erythro epimers of hepoxilin B3. An inference is drawn regarding the regulation of the plasticity of cholinoreceptors by leukotrienes B4 and C4, which are formed under the influence of 5-lipoxygenase. One of these pathways includes inositol-1,4,5-triphosphate-dependant mobilization of deposited Ca2+.

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References

  1. A. S. Pivovarov, “Cholinoreceptors of neurons of the common snail: identification, plasticity, and its regulation by opioids and second messengers”,Zh. Vyssh. Nerv. Deyat.,42, No. 6, 1271 (1992).

    CAS  Google Scholar 

  2. A. S. Pivovarov, E. I. Drozdova, Yu. Yu. Belosludtsev, et al., “Short- and long-latency effects of 15-hydroxyeicotetraenoic [sic] acid on the extinction of the acetylcholine-induced inward current of neurons of the common snail”,Byull. Éksperim. Biol. Med.,112, No. 7, 3 (1991).

    CAS  Google Scholar 

  3. A. S. Pivovarov, E. I. Drozdova, D. A. Zabolotskii, and G. I. Myagkova, “Inhibitors of the lipoxygenases, the eicosapolyynoic acids, attenuate the short-term plasticity of the cholinoreceptors of neurons of the common snail”,Zh. Vyssh. Nerv. Deyat.,41, No. 6, 1215 (1991).

    CAS  Google Scholar 

  4. A. S. Pivovarov, E. I. Drozdova, and B. I. Kotlyar, “Arachidonic acid and its acyclic derivatives regulate the short-term plasticity of cholinoreceptors of neurons of the common snail”,Zh. Vyssh. Nerv. Deyat.,41, No. 4, 796 (1991).

    CAS  Google Scholar 

  5. R. N. Skryma, L. E. Kalashnikova, V. E. Degtyar’, et al., “The action of leukotriene LTC4 on the calcium channels and tonus of smooth-muscle organs”,Neirofiziologiya,21, No. 2, 262 (1989).

    CAS  Google Scholar 

  6. L. Baud, J. Perez, G. Cherqui, et al., “Leukotriene D4-induced proliferation of glomerular epithelial cells: PKC and Na+−H+ exchanger-mediated response”,Am. J. Physiol.,257, C232 (1989).

    CAS  PubMed  Google Scholar 

  7. F. Belardetti, W. B. Campbell, J. R. Falk, et al., “Products of hemo-catalyzed transformation of the arachidonate derivative 12-HETE open S-type K+ channels inAplysia”,Neuron,3, 497 (1989).

    Article  CAS  PubMed  Google Scholar 

  8. S. Bevan and J. N. Wood, “Arachidonic acid metabolites as second messengers”,Nature,328, 20 (1987).

    Article  CAS  PubMed  Google Scholar 

  9. N. Butther, S. A. Siegelbaum, and A. Volterra, “Direct modulation ofAplysia S-K+ channels by a 12-lipoxygenase metabolite of arachidonic acid”,Nature,342, 553 (1989).

    Google Scholar 

  10. S. C. Chow, M. Joudal, and S. Orrenius, “Polyunsaturated fatty acids (pufas) induce cytosolic Ca2+([Ca2+]) increase and simultaneously block Ca2+ influx in T-cells”,FASEB J.,4, 1785 (1990).

    Google Scholar 

  11. S. T. Crooke, M. Mattern, H. M. Sarau, et al., “The signal transduction system of the leukotriene D4 receptor”,Trends Pharmacol. Sci.,10, 103 (1989).

    Article  CAS  PubMed  Google Scholar 

  12. L. O. Derewlany, C. R. Pace-Asciak, and I. C. Radde, “Hepoxilin A, hydroepoxide metabolite of arachidonic acid, stimulates transport of45Ca across the guinea pig visceral yolk sac”,Can. J. Physiol. Pharmacol.,62, 1466 (1984)

    CAS  PubMed  Google Scholar 

  13. S. Dho, S. Grinstein, E. C. Corey, et al., “Hepoxilin A3 induces changes in cytosolic calcium, intracellular pH and membrane potential in human neutrophils”,Biochem J.,266, 63 (1990).

    CAS  PubMed  Google Scholar 

  14. M. U. Erengruber and P. Zahler, “Inhibition of the nicotinic ion channels by arachidonic acid and other unsaturated fatty acids in chromaffin cells from bovine adrenal medulla”,Chimia,45, 45 (1991).

    Google Scholar 

  15. D. J. Fretland and S. W. Djuric, “12(R)- and 12(S)-hydroxyeicosatetraenoic acid: chemistry, biology and pharmacology”,Prostaglandins Leukot. Essent. Fatty Acids,38, 215 (1989).

    CAS  PubMed  Google Scholar 

  16. J. C. Louis, P. Bassel, M. O. Revei, et al., “Opposite effects of arachidonic acid and of its hydroperoxides on brain soluble guanylate cyclase activity”,Neurochem. Int.,18, 131 (1991).

    Article  CAS  Google Scholar 

  17. S. Mong, J. Miller, H.-L. Wu, and S. T. Crooke, “Leukotriene D4 receptor-mediated hydrolysis of phosphoinositide and mobilization of calcium in sheep tracheal smooth muscle cells”,J. Pharmacol. Exp. Ther.,244, 508 (1988).

    CAS  PubMed  Google Scholar 

  18. C. R. Pace-Asciak, “Arachidonic acid and epoxides. Demonstration through [18O] oxygen studies of an intramolecular transfer of the terminal hydroxyl group of (12S)-hydroperoxyeicosa-5,8,10,14-tetraenoic acid to form hydroxyepoxides”,J. Biol. Chem.,259, 8332 (1984).

    CAS  PubMed  Google Scholar 

  19. D. Piomelli, E. Shapiro, S. J. Feinmark, and J. H. Schwartz, “Metabolites of arachidonic acid in the nervous system ofAplysia: possible mediators of synaptic modulation”,J. Neurosci.,7, 3675 (1987).

    CAS  PubMed  Google Scholar 

  20. D. Piomelli, E. Shapiro, R. Zipkin, et al., “Formation and action of 8-hydroxy-11,12-epoxy-5,9,14-eicosatrienoic acid inAplysia: a possible second messenger in neurons”,Proc. Natl. Acad. Sci. USA,86, 1721 (1989).

    CAS  PubMed  Google Scholar 

  21. D. Piomelli, A. Volterra, N. Dale, et al., “Lipoxygenase metabolites of arachidonic acid as second messengers for presynaptic inhibition ofAplysia sensory cells”,Nature,328, 38 (1987).

    Article  CAS  PubMed  Google Scholar 

  22. D. Piomelli, J. K. Wong, T. S. Sihra, et al., “Inhibition of Ca2+/calmodulin-dependant protein kinase II by arachidonic acid and its metabolites”,Proc. Natl. Acad. Sci. USA,86, 8550 (1989).

    CAS  PubMed  Google Scholar 

  23. B. Samuelsson, “The leukotrienes: an introduction”, in:Advances in Prostaglandin, Tromboxane, and Leukotriene Res. Ser. Vol. 9. Leukotrienes and Other Lipoxygenase Products, B. Samuelsson and R. Paoletti (eds.), Raven Press, N.Y., (1982), p. 1.

    Google Scholar 

  24. M. S. Simonson, P. Mené, G. R. Dubyak, and M. J. Dunn, “Identification and transmembrane signaling of leukotriene D4 receptors in human mesangial cells”Am. J. Physiol.,255, C771 (1988).

    CAS  PubMed  Google Scholar 

  25. J. D. Winkler, S. Mong, and S. T. Crooke, “Leukotriene D4-induced homologous desensitization of calcium mobilization in rat basophilic leukemia cells”,J. Pharmacol. Exp. Ther.,244, 449 (1988).

    CAS  PubMed  Google Scholar 

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Authors
  1. A. S. Pivovarov
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M. V. Lomonosov Moscow State University. Translated from Zhurnal Vysshei Nervnoi Deyatel’nosti imeni I. P. Pavlova, Vol. 44, No. 3, pp. 575–584, May–June, 1994.

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Pivovarov, A.S. Influence of leukotrienes B4 and C4, 12-hydroxy-eicosatetraenoic acid, and erythro epimers of hepoxilin B3 on the plasticity of cholinoreceptors of neurons of the common snail. Neurosci Behav Physiol 25, 361–369 (1995). https://doi.org/10.1007/BF02359592

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  • DOI: https://doi.org/10.1007/BF02359592

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