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Characterization of myxovirus sialidase

  • Specialia Chimica, Biochimica
  • Published:
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Zusammenfassung

Die Sialidasen von Myxoviren zeigten eine ähnliche Substratspezifität wie die Streptomyces-Sialidase. Siastatin A und B, Produkte von Streptomycesarten, wurden auf ihre hemmende Wirkung gegen Sialidasen verschiedenster Herkunft untersucht und als spezifische Hemmstoffe gegen bakterielle Sialidasen erkannt. Siastatin A und B hemmen die Sialidase der Chorioallantoismembran, nicht aber die Sialidasen von Myxoviren. Daraus folgt, dass virale Sialidasen in infizierten Wirtszellen de novo zusammengesetzt werden.

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Author notes

  1. K. Nerome

    Present address: National Institute of Health, Shinagawa-ku, Tokyo, (Japan)

Authors and Affiliations

  1. Institute of Microbial Chemistry, 3-14-23, Kamiosaki, Shinagawa-ku, Tokyo, (Japan)

    T. Aoyagi, T. Komiyama, K. Nerome, T. Takeuchi & H. Umezawa

  2. National Institute of Health, Shinagawa-ku, Tokyo, (Japan)

    T. Aoyagi, T. Komiyama, T. Takeuchi & H. Umezawa

Authors
  1. T. Aoyagi
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  2. T. Komiyama
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  3. K. Nerome
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  4. T. Takeuchi
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  5. H. Umezawa
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Aoyagi, T., Komiyama, T., Nerome, K. et al. Characterization of myxovirus sialidase. Experientia 31, 896–898 (1975). https://doi.org/10.1007/BF02358837

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  • DOI: https://doi.org/10.1007/BF02358837

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