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Cyclic nucleotides vs. adenosine analogs as inhibitors of adenylate cyclase activity: Nonidentity of sites of action

  • Specialia Chimica, Biochimica
  • Published:
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Zusammenfassung

Substitution einerN 6-Aminogruppe eines zyklischen Nukleotids führt zu einer erhöhten Hemmwirkung des Nukleotids gegenüber Adenyl-Cyclase von Meerschweinchenlungen, während dieN 6-Amino-Substition von Adenosin-Analogen eine herabgesetzte Inhibitionswirksamkeit gegenüber demselben Enzym zur Folge hat. Die experimentellen Daten führen zu dem Schluss, dass der Inhibitionsmechanismus gegenüber Cyclase für beide Verbindungstypen verschieden ist.

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Literatur

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Authors and Affiliations

  1. Department of Biochemical Pharmacology, Squibb Institute for Medical Research, P.O. Box 4000, 08540, Princeton, New Jersey, USA

    I. Weinryb & I. M. Michel

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  1. I. Weinryb
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  2. I. M. Michel
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Weinryb, I., Michel, I.M. Cyclic nucleotides vs. adenosine analogs as inhibitors of adenylate cyclase activity: Nonidentity of sites of action. Experientia 31, 892–894 (1975). https://doi.org/10.1007/BF02358835

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  • DOI: https://doi.org/10.1007/BF02358835

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