Abstract
Tightly coiled spiral micro-organisms (Gastrospirillum hominis), distinct fromHelicobacter pylori, were found in the gastric mucosa of a 66-year-old man with a 4-month history of intermittent epigastric pain. The organisms were distributed in the antral mucosa, which showed erosive gastritis; histologically, the affected mucosa presented moderate to severe chronic gastritis with focal neutrophil infiltration. After a 2-week administration of cimetidine, his symptoms resolved and the active inflammation was reduced, both endoscopically and histologically, but the organisms still remained. Biopsy specimens taken 4 weeks after treatment with minocycline and cimetidine showed normal gastric mucosa without the spiral organisms. The above clinical course suggests the possible role ofGastrospirillum hominis in the pathogenesis of gastritis.
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References
Blaser MJ. Gastric Campylobacter-like organisms, gastritis, and peptic ulcer disease. Gastroenterology 1987;93:371–383.
Dooley CP, Cohen H. The clinical significance ofCampylobacter pylori. Ann Intern Med 1988;108:70–79.
Dent JC, McNulty CAM, Uff JC, et al. Spiral organisms in the gastric antrum. Lancet 1987;II:96.
McNulty CAM, Dent JC, Curry A, et al. New spiral bacterium in gastric mucosa. J Clin Pathol 1989;42:585–591.
Morris A, Ali MR, Thomsen L, et al. Tightly spiral shaped bacteria in gastric antrum: Are they urease-positive? J Clin Pathol 1989;42:216–219.
Fisher R, Sämisch W, Schwenke E. “Gastrospirillum hominis”: Another four cases. Lancet 1990;335:59.
Krienitz W. Über das Auftreten von Spirochäten verschiedener Form im Mageninhalt bei Carcinoma ventriculi. Deutsch Med Wochenschr 1906;32:872.
Weber AF, Hasa O, Sautter JH. Some observations concerning the presence of spirilla in the fundic glands of dogs and cats. Am J Vet Res 1958;18:677–680.
Weber AF, Schmittdiel EF. Electron microscopic and bacteriologic studies of spirilla isolated from the fundic stomachs of cats and dogs. Am J Vet Res 1962;23:422–427.
Warren JR. Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet 1983;I:1273.
Marshall BJ. Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet 1983;I:1273–1274.
Waring PM, Shilkin KB. “Corkscrew-like” bacteria associated with gastritis. Histopathology 1989;15:647–649.
Logan RPH, Polson RJ, Baron JH, Walker MM. New spiral bacterium in the gastric mucosa:Gastrospirillum hominis. J Clin Pathol 1990;43:262–263.
Lord MG, Taylor CJ, Nour S.Gastrospirillum hominis infection of the stomach. Lancet 1989;II:627.
Dubois A, Tarnawski A, Newell DG, et al. Gastric injury and invasion of parietal cells by spiral bacteria in rhesus monkeys. Are gastritis and hyperchlorhydria infectious diseases? Gastroenterology 1991;100:884–891.
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Tanaka, M., Saitoh, A., Narita, T. et al. Gastrospirillum hominis-associated gastritis: The first reported case in Japan. J Gastroenterol 29, 199–202 (1994). https://doi.org/10.1007/BF02358683
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DOI: https://doi.org/10.1007/BF02358683