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Immunohistochemical study of the distribution of intercellular adhesion molecule-1 and lymphocyte function-associated antigen-1 in chronic type B hepatitis

  • Liver, Pancreas, and Biliary Tract
  • Published:
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Abstract

The expression of intercellular adhesion molecule-1 (ICAM-1) and lymphocyte function-associated antigen-1 (LFA-1) in the livers of 11 patients with chronic hepatitis B was studied immunohistochemically by light and electron microscopy to clarify the role of these adhesion molecules in tissue damage in chronic hepatitis B. On hepatocytes, ICAM-1 expression was confined to the bile canalicular surface when the liver inflammation was mild. In contrast, when the liver inflammation was severe, ICAM-1 was distributed on the entire surface of the hepatocyte, including the sinusoidal and lateral membranes; lymphocytes which were mostly positive for LFA-1, were often observed invading deeply among these hepatocytes. The degree of ICAM-1 expression on the hepatocytes was also related to the expression of HLA class 1 antigen. In liver showing diffuse expression of ICAM-1 on the hepatocytes, strong expression of HLA class 1 antigen was observed, and amounts of HBV in the liver were decreased. Diffuse expression of ICAM-1 and HLA class 1 antigen was mostly observed after acute exacerbation of liver inflammation. These results suggest that the ICAM-1/LFA-1 pathway is involved in the immunological mechanism, responsible for liver cell damage in chronic hepatitis B.

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Authors and Affiliations

  1. The First Department of Internal Medicine, Okayama University Medical School, 2-5-1, 700, Okayama, Japan

    Toshihiko Doi, Gotaro Yamada, Motowo Mizuno & Takao Tsuji

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  1. Toshihiko Doi
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  2. Gotaro Yamada
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  3. Motowo Mizuno
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  4. Takao Tsuji
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Doi, T., Yamada, G., Mizuno, M. et al. Immunohistochemical study of the distribution of intercellular adhesion molecule-1 and lymphocyte function-associated antigen-1 in chronic type B hepatitis. J Gastroenterol 29, 164–171 (1994). https://doi.org/10.1007/BF02358678

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  • DOI: https://doi.org/10.1007/BF02358678

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