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Elevation of N1-acetylspermidine and putrescine in hepatic tissues of patients with fulminant hepatitis and liver cirrhosis

  • Liver, Pancreas, and Biliary Tract
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Abstract

Hepatic polyamines were assayed in 15 patients with liver diseases, 5 with fulminant hepatitis (FH); 3 with exacerbated liver cirrhosis (ELC); and 7 with liver cirrhosis (LC). Hepatic putrescine and N1-acetylspermidine, as percentages of total polyamines, were elevated and spermine was decreased in all 15 patients. The increase in hepatic N1-acetylspermidine levels appeared to be greater in patients with FH and ELC than in those with LC. These results suggest that the production of N1-acetylspermidine in human liver is closely associated with the induction of spermidine/spermine N1-acetyltransferase activity in liver diseases.

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Authors and Affiliations

  1. Department of Physiology, Institute of Endocrinology, School of Medicine, Gunma University, 3-39-15 Showa-machi, 371, Maebashi, Japan

    Hiroyuki Sugimoto & Shigeru Matsuzaki

  2. First Department of Internal Medicine, School of Medicine, Gunma University, 3-39-15 Showa-machi, 371, Maebashi, Japan

    Seiji Sakurai, Takehiko Abe, Hitoshi Takagi, Hitomi Takahashi, Jiro Takezawa & Takeaki Nagamine

Authors
  1. Hiroyuki Sugimoto
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  2. Seiji Sakurai
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  3. Takehiko Abe
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  4. Hitoshi Takagi
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  5. Hitomi Takahashi
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  6. Jiro Takezawa
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  7. Takeaki Nagamine
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  8. Shigeru Matsuzaki
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Sugimoto, H., Sakurai, S., Abe, T. et al. Elevation of N1-acetylspermidine and putrescine in hepatic tissues of patients with fulminant hepatitis and liver cirrhosis. J Gastroenterol 29, 159–163 (1994). https://doi.org/10.1007/BF02358677

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  • DOI: https://doi.org/10.1007/BF02358677

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