Abstract
In recent years, many cases of alpha-fetoprotein-producing gastric cancer (AFPGC) characterized by increased serum levels of alpha-fetoprotein (AFP) and AFP positivity of the gastric cancer have been reported. Here we present a case of AFPGC coexistent with a different histological type of gastric cancer: The AFPGC was Borrmann type 1 advanced gastric cancer with multiple liver metastasis and appeared to produce both AFP and des-γ-carboxy prothrombin (PIVKA-II). The second cancer was IIc type early gastric cancer and did not produce AFP. Despite receiving palliative chemotherapy, the patient died, due to hepatic failure, 45 days after admission.
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References
Bergstrand CT, Czar D. Demonstration of a new protein fraction in the serum from the human fetus. Scand J Clin Lab Invest 1956;8:174.
Bourreille J, Metayer P, Sauger F, et al. Existence d'alpha foeto proteine au cours d'un cancer secondaire du foie d'origine gastrique. Presse Med 1970;78:1277–1278.
Taketa K. Distinct molecular species of human alpha-fetoprotein due to differentiated affinities to lectins. Ann NY Acad Sci 1983;417:61–68.
Ishiguro T. Serum alpha-fetoprotein subfractions in patient with primary hepatoma or hepatic metastasis of gastric cancer. Cancer 1985;55:156–159.
Kubo T, Sowa M, Nishimura M, et al. Clinicopathological study of primary gastric cancer with high serum levels of alpha-fetoprotein (in Japanese). Nippon Syokakigeka Gakkai Zasshi 1989;22:1761–1767.
Matsunou H, Konishi F, Jalal RE, et al. Alpha-fetoprotein-producing gastric carcinoma with enteroblastic differentiation. Cancer 1994;73:534–540.
Caruso RA. Hepatoid gasric adenocarcinoma. A histological and immunohistochemical study of a case. Eur J Basic Appl Histochem 1991;35:203–209.
Chang YC, Nagasue N, Abe S, et al. Comparison between the clinicopathologic features of AFP-positive and AFP-negative gastric cancers. Am J Gastroenterol 1992;87:321–325.
Uefuji K, Ichikura T, Tamakuma S. Roles of histological findings and serum AFP levels in the prognosis of AFP-producing gastric cancers. Jpn J Clin Oncol 1994;24:135–140.
Motoyama T, Aizawa K, Watanabe H, et al. Alpha-fetoprotein-producing gastric carcinomas: A comparative study of three different subtypes. Acta Pathol Jpn 1993;43:654–661.
Ooi A, Nakanishi I, Sakamoto N, et al. Alpha-fetoprotein (AFP)-producing gastric carcinoma. Is it hepatoid differentiation. Cancer 1990;65:1741–1747.
Kudo M, Takamine Y, Nakamura K, et al. Des-gamma-carboxy prothrombin (PIVKA-II) and alpha-fetoprotein-producing IIc-type early gastric cancer. Am J Gastroenterol 1992;87:1859–1862.
deLorimier A, Park F, Aranha GV, et al. Hepatoid carcinoma of the stomach. Cancer 1993;71:293–296.
Sawada H, Nakatani K, Watanabe A, et al. The potential for the development of liver metastasis from alpha-fetoprotein-producing human gastric carcinomas in nude mice. Jpn J Clin Oncol 1992;22:303–307.
Chang YC, Nagasue N, Kohno H, et al. Clinicopathologic features and long-term results of alpha-fetoprotein-producing gastric cancer. Am J Gastroenterol 1990;85:1480–1485.
Chang YC, Nagasue N, Kohno H, et al. Xenotransplantation of alpha-fetoprotein-producing gastric cancers into nude mice. Characteristics and responses to chemotherapy. Cancer 1992;69:872–827.
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Hyodo, T., Kawamoto, R. Double cancer of the stomach, one AFP-producing tumor. J Gastroenterol 31, 851–854 (1996). https://doi.org/10.1007/BF02358614
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DOI: https://doi.org/10.1007/BF02358614