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Journal of Gastroenterology

, Volume 31, Issue 6, pp 777–784 | Cite as

Evaluation of omental implantation for perforated gastric ulcer therapy: Findings in a rat model

  • Yasunori Matoba
  • Hironori Katayama
  • Hiroshi Ohami
Alimentary Tract

Abstract

Omental implantation, a surgical procedure in which a perforated gastric or duodenal ulcer is repaired by drawing and implanting a portion of the omentum into the digestive tract, accelerates ulcer healing and inhibits ulcer recurrence. However, the mechanisms underlying these beneficial effects are largely unknown. To clarify these mechanisms, we investigated ulcer healing in two groups of rats in which acetic acid-induced gastric ulcers were perforated. Omental implantation was used for repair in one group and simple suturing was employed in the other group. Greater antiinflammatory and angiogenic activity and accelerated collagen synthesis were seen in the omental implantation group. Basic fibroblast growth factor (bFGF)-mediated angiogenesis was noted in this group, as well as transforming growth factor-β1 (TGF-β1) activity within and around the omentum, resulting in abundant collagen production. It was confirmed that omental implantation accelerated ulcer healing and inhibited ulcer recurrence, and the presence of bFGF and TGF-β1 played a significant role in both these phenomena.

Key words

omental implantation omentum perforated gastro-duodenal ulcer ulcer recurrence growth factor 

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Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • Yasunori Matoba
    • 1
  • Hironori Katayama
    • 2
  • Hiroshi Ohami
    • 3
  1. 1.Center for Digestive Diseases, Nippon Medical SchoolSecond HospitalKanagawaJapan
  2. 2.Department of Pathology, Nippon Medical SchoolTama-Nagayama HospitalTokyoJapan
  3. 3.Research Institute of GerontologyNippon Medical SchoolKanagawaJapan

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