Abstract
A comparative investigation has been carried out for the first time of the receptor binding of glutamate with synaptic membranes and coarse fractions of the postsynaptic enlargements isolated from the striatum of rats differing in their capacity to develop an alimentary instrumental reflex. It was demonstrated that the number of that glutamate binding sites on the postsynaptic enlargements isolated from the striatum of rats capable of rapidly developing an alimentary instrumental reflex was increased as compared with animals not subjected to training. This relationship is maintained two months after the termination of training.
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References
S. A. Dambinova and A. I. Gorodinskii, “The molecular organization of glutamate-sensitive chemoexcitable membranes of nerve cells. The binding of L-[H3]-glutamate with synaptic membranes of the cerebral cortex of rats,” Biokhimiya,49, No. 1, 67–75 (1984).
S. V. Zaitsev, I. N. Kurochkin, M. G. Sergeeva, and S. D. Varfolomeev, “The stability of opiate receptors of ‘wet’ and allophanized preparations of membranes of the brain of rats,” Biokhimiya,49, No. 7, 1127–1133 (1984).
I. V. Karpova, “The content of dopamine, its metabolites, and GABA in the nigrostriatal system in rats with different capacities for learning,” Zhurn. Vyssh. Nervn. Deyat.,42, No. 1, 161–163 (1992).
N. F. Suvorov, The Striatal System and Behavior [in Russian], Leningrad (1980).
N. F. Suvorov, “The neurochemical corticostriatal mechanisms of the conditioned reflex,” in: Brain and Behavior, M. G. Airapetyants (ed.) [in Russian], Moscow (1990), pp. 156–168.
G. E. Yule and M. Kendall, The Theory of Statistics [Russian translation], Moscow (1960).
R. K. S. Calverley and D. G. Jones, “Contribution of dendritic spines and perforated synapses to synaptic plasticity,” Brain Res. Rev.,15, No. 3, 215–259 (1990).
R. S. Cohen, F. Blomberh [sic], K. Berzins, and P. Siekevitz, “The structure of postsynaptic densities isolated from dog cerebral cortex. Overall morphology and protein composition,” J. Cell Biol.,74, No. 1, 181–203 (1977).
M. Errami and A. Nieoullon, “Developments of a micromethod to study the Na+-independent L-[3H]-glutamic acid binding to rat striatal membranes. I. Biochemical and pharmacological characterization,” Brain Res.,366, No. 1–2, 169–177 (1986).
A. C. Foster and E. Fagg, “Comparison of L-[3H]-glutamate, D-3H aspartate, DL[3H] APS and [3H] NMDA as ligands for NMDA receptors in crude postsynaptic densities from rat brain,” Eur. J. Pharmacol.,33, No. 3, 291–300 (1987).
W. Hauber and W. J. Schmidt, “Effects of interstriatal [sic] blockade of glutamatergic transmission on the acquisition of T-maze and radial maze tasks,” J. Neural Transmiss.,78, No. 1, 29–41 (1989).
G. Horn and B. J. McCabe, “The time course of N-methyl-D-aspartate (NMDA) receptor binding in chick brain after imprinting,” J. Physiol.,423, 92P (1990).
R. M. A. Jaspers, T. J. de Vries, and A. R. Cocls, “Effects of intrastriatal apomorphine on changes in switching behavior induced by the glutamate agonist AMPA injected into the cat caudate nucleus,” Behav. Brain Res.,37, No. 3, 247–254 (1990).
M. B. Kennedy, “Regulation of synaptic transmission in the central nervous system: long-term potentiation,” Cell,59, No. 5, 777–787 (1989).
A. Luini, O. Goldberg, and V. I. Teichberg, “Differential selectivity of selected brain areas to excitatory amino acids,” Neurosci. Lett.,41, No. 3, 307–312 (1983).
G. Lyhch [sic] and M. Baudry, “The biochemistry of memory: a new and specific hypothesis,” Science,224, No. 4653, 1057–1063 (1984).
L. A. Mamonas, R. F. Thompson, G. Lynch, and M. Baudry, “Classical conditioning of the rabbit eyelid response increases glutamate receptor binding in hippocampal synaptic membranes,” Proc. Nat. Acad. Sci. USA,81, No. 8, 2548–2552 (1984).
R. G. M. Morris, “Elements of hypothesis concerning the participation of hippocampal NMDA-receptors in learning,” in: Excitatory Amino Acids in Health and Disease, D. Lodge (ed.), London (1988), pp. 297–320.
G. Scatchard, “The attraction of proteins for small molecules and ions,” Ann. N. Y. Acad. Sci.,51, No. 4, 479–486 (1949).
B. Scatton and J. Lehmann, “N-methyl-D-aspartate type receptors mediate atriatal [3H]-acetylcholine release evoked by excitatory amino acids,” Nature (London),297, No. 5865, 422–424 (1982).
J. Tonkies, R. J. M. Morris [sic], and J. N. P. Rawlings, “Intra-ventricular infusion of the NMDA antagonist APS impairs performance on a non-spatial operant DRL task in the rat,” Exptl Brain Res.,73, No. 1, 181–188 (1988).
K. Wu, C. Waserlain, L. Sachs, and P. Siekevitz, “Effect of septal kindling on glutamate binding and calmodulin-dependent phosphorylation in a postsynaptic density fraction isolated from rat cerebral cortex,” Proc. Nat. Acad. Sci. USA,87, No. 14, 5298–5302 (1990).
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Laboratory of Physiology of Higher Nervous Activity, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, Saint Petersburg. Laboratory of Molecular Neurobiology, Institute of Human Brain, Russian Academy of Sciences, Saint Petersburg. Translated from Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 80, No. 1, pp. 72–77, January, 1994.
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Karpova, I.V., Gorodinskii, A.I., Suvorov, N.F. et al. Receptor binding of glutamate in the striatum of rats differing in learning capacity. Neurosci Behav Physiol 25, 98–103 (1995). https://doi.org/10.1007/BF02358575
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DOI: https://doi.org/10.1007/BF02358575