Journal of Gastroenterology

, Volume 29, Issue 3, pp 385–387 | Cite as

Effect of a new cholecystokinin antagonist (FK 480) on gene expression of cholecystokinin and secretin in rat intestine

  • Akihiro Funakoshi
  • Kyoko Miyasaka
Rapid Communication


The effects of a new cholecystokinin (CCK) antagonist (FK 480; 0.1 mg/kg per day given by intragastric administration to rats for 3 days) on the expression of the CCK and secretin genes, plasma CCK immunoreactivity, and CCK content in the intestinal mucosa were examined. FK 480 increased the level of CCK mRNA in the intestine to 1.7 times the level in control rats, but did not affect the level of secretin mRNA. It did not increase plasma CCK immunoreactivity or CCK content in the intestinal mucosa. These results suggest that the ingested FK 480 directly increased CCK mRNA level in the intestine and produced a dissociation between the synthesis and release of CCK.

Key words

CCK antagonist (FK 480) gene expression CCK secretin 


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Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • Akihiro Funakoshi
    • 1
  • Kyoko Miyasaka
    • 2
  1. 1.Department of GastroenterologyNational Kyushu Cancer CenterFukuokaJapan
  2. 2.Department of Clinical PhysiologyTokyo Metropolitan Institute of GerontologyTokyoJapan

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