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Tropical Animal Health and Production

, Volume 23, Issue 4, pp 197–202 | Cite as

Crossprotective immunity between the Florida and a Zimbabwe stock ofAnaplasma marginale

  • Ntando Tebele
  • Guy H. Palmer
Article

Summary

Cattle immunised by infection with the Florida stock ofAnaplasma marginale were protected against subsequent homologous challenge, as demonstrated by complete prevention of microscopically detectable parasitaemia. Identically immunised cattle were partially protected against challenge with the Norton, Zimbabwe stock ofA. marginale as determined by the significant prolongation of the prepatent period, a significantly lower peak parasitaemia and a significantly lower percentage drop in haemoglobin concentration when compared to non-immunised calves challenged identically. The partial protection induced by live Florida stock immunisation demonstrates that while protection-inducing epitopes are shared between the two stocks, induction of complete immunity against a Zimbabwe stock may require alternative presentation of Florida stock epitopes or inclusion of additional Zimbabwe stock epitopes in the immunogen.

Keywords

Como Haemoglobin Concentration Condition Analogue Floride Partial Protection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Résumé

Du bétail immunisé après une infection avec le stock Floride d'Anaplasma marginale a été protégé d'un risque d'infection homologue ultérieur, comme l'a révélé la prévention complète d'une parasitémie décelable au microscope. Du bétail immunisé dans des conditions analogues s'est trouvé partiellement protégé d'une infection par le stock Norton du Zimbabwe. Confirmation en a été donnée par l'allongement significatif de la période prépatente, un pic significantivement plus bas de la pourcentage de la concentration en hémoglobine, par comparaison avec des veaux non immunisés et soumis au même risque. Alors que les épitopes qui engendrent la protection sont partagés entre les 2 stocks, la protection partielle induite par l'immunisation à l'aide du stock vivant Floride montre que la création d'une immunité compléte contre un stock Zimbabwe peut exiger soit la présence alternative d'épitopes du stock Floride, soit l'inclusion dans le gène d'immunité d'épitopes provenant du stock Zimbabwe.

Resumen

Cuando se inmunizó ganado contra anaplasmosis con la Cepa Florida deAnaplasma marginale, éstos estuvieron protegidos contra descargas homólogas, como se demostró por la ausencia de parasitemia microscópica. También, el ganado inmunizado con la referida Cepa, se inmunizó del período prepatente, parasitemia baja y caída insignificante de hemoglobina, comparando los animales con aquellos no inmunizados, los que fueron descargados igualmente.

La protección parcial inducida con la Cepa Florida demuestra, que si bien existe cierta inmunidad cruzada con la Cepa Zimbabwe las cuales comparten ciertos epítopos, la inducción de una completa inmunidad tal vez requiere la presentación alternativa de los epítopos de la Cepa Florida o la inclusión de epítopos adicionales de la Cepa Zimbabwe en el inmunógeno.

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Copyright information

© Centre for Tropical Veterinary Medicine 1991

Authors and Affiliations

  • Ntando Tebele
    • 1
  • Guy H. Palmer
    • 2
  1. 1.Veterinary research LaboratoryCausewayZimbabwe
  2. 2.Department of Veterinary Microbiology and PathologyWashington State UniversityPullmanUSA

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