Tropical Animal Health and Production

, Volume 3, Issue 1, pp 26–31 | Cite as

Oxyclozanide—Activity against fasciola gigantica in naturally infected buffalo, cattle, sheep and goats

  • R. M. Roy
  • S. S. Sukhla
Article

Summary

The activity of oxyclozanide was studied in buffalo, cattle, sheep and goats naturally infected withFasciola gigantica.

The results indicate a very high efficiency against flukes aged six weeks or more. The drug was also observed to have considerable action on hepatic and ruminal amphistomes. No toxic side-effects were observed in any of the animals treated, except slight softening of faeces with increased frequency of defaecation and inappetance in a few animals. This was observed more frequently in buffalo than in cattle. Sheep and goats were less affected. A transient drop in milk yield for about two to three days was observed in a few animals. No ill effects were observed in experimental animals which were maintained on highly nitrogenous diets. The drug was also well-tolerated by pregnant animals.

Keywords

Public Health Indican Experimental Animal Veterinary Medicine Milk Yield 

Résumé

L'activité de l'oxyclozanide a été étudiée chez les buffles, les bovins, les moutons et les chèvres naturellement infestés parF. gigantica.

Les résultats révèlent une trés haute efficacité contre les douves âgées de six semaines ou plus. Ce produit se montra aussi très actif sur les amphistomes du foie et du rumen. Aucun effet toxique associé ne fut observé chez les animaux traités, excepté un léger ramollissement des fèces, un accroissement de la fréquence des défécations et de l'inappétence chez un petit nombre d'animaux. Cela fut observé plus souvent chez les buffles que chez les bovins. Chèves et moutons furent moins affectés. On observa chez quelques animaux une baisse temporaire de la production lactée durant deux à trois jours. Aucune réaction défavorable n'apparut chez les animaux d'expérience soumis à régime à forte teneur en azote. Le produit est aussi bien toléré par les femelles en gestation.

Sumario

Se estudió la actividad del oxyclozanide en búfalos, bovinos, ovinos y caprinos infectados naturalmente conFasciola gigantica.

Los resultados indican una eficiencia muy alta contra Fasciolas de 6 semanas ó mas. La droga tuvo también una acción considerable sobre los amfistomas hepáticos y ruminales. No se observaron efectos colaterales tóxicos en los animales tratados, excepto por el ligero ablandamiento de las heces con un incremento de la frecuencia en la defecación e inapetencia en algunos animales. Esto se observó mas frecuentemente en búfalos que en bovinos. Los ovinos y caprinos fueron menos afectados. Se observó una disminución transitoria en la producción de leche de algunos animales la cual duró de dos a tres dias. No se observaron efectos nocivos en los animales en experimentación que fueron mantenidos con dietas altas en nitrógeno. La droga fué tolerada bastante bien por animales en gestación.

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References

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Copyright information

© E. & S. Livingstone 1971

Authors and Affiliations

  • R. M. Roy
    • 1
  • S. S. Sukhla
    • 2
  1. 1.Disease Investigation OfficerVeterinary Biological and Research InstituteHyderabadIndia
  2. 2.Veterinary Surgeon in charge, Experimental StationFascioliasis schemeBanswandaIndia

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