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Tropical Animal Health and Production

, Volume 2, Issue 4, pp 196–203 | Cite as

Chemotherapy of experimentalBabesia bigemina infections with imidocarb dihydrochloride

  • C. G. D. Brown
  • J. Berger
Article

Summary

Chemotherapeutic trials with a new babesicide 3,3′-bis-(2-imidazolin-2-yl) carbanilide dihydrochloride (4A65) are reported. The drug was shown to be highly effective in the control of risingBabesia bigemina parasitaemias in experimentally infected splenectomized calves. Administered subcutaneously or intramuscularly at levels down to 1 mg/kg and intravenously at dose rates as low as 0·125 mg/kg imidocarb dihydrochloride suppressed both the multiplication of the parasite and the development of anaemia in acute infections. Toxicity observations indicated a high therapeutic index.

Keywords

Public Health Anemia Dose Rate Carb Veterinary Medicine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Résumé

Des essais thérapeutiques avec un nouveau piroplasmicide, le 3,3′-bis-(2-imidazolin-2-yl) carbanilide dichlorhydrate (4A65), sont reportés. Ce produit s'est montré hautement efficace pour faire disparaître les parasitémies récentes àBabesia bigemina chez les veaux splénectomisés et artificiellement infectés. L'imidocarb-dichlorhydrate administré par la voie sous-cutanée ou intramusculaire à la dose de 1 mg/kg et par la voie intraveineuse à une dose aussi faible que 0,125 mg/kg, a supprimé à la fois la multiplication du parasite et l'évolution de l'anémie dans les infections aiguës. Les tests de toxicité ont révélé un index thérapeutique élevé.

Sumario

Se reportan intentos quimioterapéuticos con una nueva droga contra las babesias. (3,3′-bis-(2-imidazolin-2-yl) carbanilide dihydrochloride (4A65). Se demostró que la droga fue altamente efectiva en el control de parasitemias ascendientes deBabesia bigemina en terneros esplenectomizados experimentalmente infectados. Ineyctado porla via subcutanea ó intramuscular en niveles de hasta 1 mg/Kg y por la via endovenosa en dosis tan bajas como o.125 mg/Kg, el imido carb diclorhidrato suprimió tanto la multiplicación del parásito como el desarrollo de anemia en las infecciones agudas. Las observaciones de toxicidad indicaron un índice altamente terapéutico.

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References

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Copyright information

© E. & S. Livingstone 1970

Authors and Affiliations

  • C. G. D. Brown
    • 1
  • J. Berger
    • 1
  1. 1.Wellcome Research Laboratory (E. Africa)KabeteKenya

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