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State of hypophyseogonadal system in male rats with diabetes (experimental investigation)

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Conclusions

  1. 1.

    The level of LH and FSH in the blood of male rats did not change during the development of experimental diabetes; the concentration of T decreased.

  2. 2.

    The sensitivity of the hypophysis to LH-RH in rats that have received STZ declined sharply when it was incubated for more than 1 h.

  3. 3.

    A decrease in the concentration of the nuclear T receptors in the adenohypophysis was observed during the development of experimental diabetes.

  4. 4.

    The alterations in the concentration of hormones in the blood and in the level of androgen receptors in the hypophysis of rats receiving STZ were restored through insulin replacement therapy.

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Authors and Affiliations

  1. Laboratory of the Physiology of the Endocrine System, Institute of Experimental Endocrinology, Moscow

    V. N. Babichev, T. A. Peryshkova & E. I. Adamskaya

  2. Endocrinological Scientific Center, Institute of Experimental Endocrinology, Moscow

    V. N. Babichev, T. A. Peryshkova & E. I. Adamskaya

Authors
  1. V. N. Babichev
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  2. T. A. Peryshkova
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  3. E. I. Adamskaya
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Translated from Problemy Éndokrinologii, Vol. 39, No. 1, pp. 42–45, January–February, 1993.

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Babichev, V.N., Peryshkova, T.A. & Adamskaya, E.I. State of hypophyseogonadal system in male rats with diabetes (experimental investigation). Neurosci Behav Physiol 24, 159–162 (1994). https://doi.org/10.1007/BF02355673

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  • DOI: https://doi.org/10.1007/BF02355673

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