Journal of Gastroenterology

, Volume 31, Issue 4, pp 582–584 | Cite as

Ischemic colitis during interferon-alpha treatment for chronic active hepatitis C

  • Hisashi Tada
  • Shoichi Saitoh
  • Yoshihiro Nakagawa
  • Hirofumi Hirana
  • Michio Morimoto
  • Toshihide Shima
  • Kazuhiko Shimamoto
  • Takeshi Okanoue
  • Kei Kashima
Case Report

Abstract

Between 1991 and 1994, at Hoshigaoka Koseinenkin Hospital, we treated 280 patients with chronic hepatitis C with interferon (IFN), and ischemic colitis occurred in two patients (0.7%) during the treatment. Melena appeared in case 1 in the 2nd month after the initiation of IFN-alpha treatment, and in case 2 in the 6th month. In both patients, longitudinal ulcerations in the descending colon were revealed by urgent colonoscopy, and these resolved within 2 weeks after discontinuation of the IFN treatment. It appears that ischemic colitis was associated with the IFN treatment, suggesting that attention should be paid to this possible complication.

Key words

interferon chronic hepatitis C side effect ischemic colitis 

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Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • Hisashi Tada
    • 1
  • Shoichi Saitoh
    • 1
  • Yoshihiro Nakagawa
    • 1
  • Hirofumi Hirana
    • 1
  • Michio Morimoto
    • 1
  • Toshihide Shima
    • 1
  • Kazuhiko Shimamoto
    • 1
  • Takeshi Okanoue
    • 2
  • Kei Kashima
    • 2
  1. 1.Division of Gastroenterology, Internal MedicineHoshigaoka Koseinenkin HospitalHirakata, OsakaJapan
  2. 2.Department of Internal MedicineKyoto Prefectural University of MedicineKyotoJapan

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