Journal of Gastroenterology

, Volume 31, Issue 3, pp 470–474 | Cite as

Gallbladder cancer associated with cholesterosis

  • Takayoshi Akiyama
  • Hiroyuki Sahara
  • Keitaro Seto
  • Hitoshi Saitou
  • Masato Kiriyama
  • Fujio Tomita
  • Takeo Kosaka
  • Ichirou Kita
  • Shigeki Takashima
  • Hisao Matsunou
Case Report

Abstract

We report herein two cases of carcinoma in situ of the gallbladder associated with cholesterosis. The patient in case 1 was an 81-year-old man who underwent a cholecystectomy for cholelithiasis. The resected specimens revealed gallbladder cancer in the fundus which was diagnosed histologically as mucinous carcinoma. Other findings included 13-mm, 12-mm, and 5-mm poly-poid lesions in the neck of the gallbladder which macroscopically appeared to be cholesterol polyps, but histologically demonstrated carcinoma in situ with cholesterosis. The patient in case 2 was a 76-year-old man in whom ultrasonography revealed a highly echogenic, elevated lesion in the gallbladder. Cholecystectomy was performed, and a 33×28-mm papillary, elevated lesion with cholesterosis was resected from the neck of the gallbladder. Histologically, this was demonstrated to be papillary adenocarcinoma in situ with cholesterosis surrounded by glandular dysplasia. The distribution of the carcinomas and cholesterosis in both of these patients suggests that the adenoma or carcinoma of the gallbladder had occurred first. Then, the tumor epithelium absorbed cholesterol from the bile, and foamy cells were produced. Thus, when treating cholesterol polyps, it should be remembered that it is often difficult to distinguish between cholesterol polyp and gallbladder cancer with cholesterosis.

Key words

gallbladder cancer cholesterosis cholesterol polyp 

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Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • Takayoshi Akiyama
    • 1
  • Hiroyuki Sahara
    • 1
  • Keitaro Seto
    • 1
  • Hitoshi Saitou
    • 1
  • Masato Kiriyama
    • 1
  • Fujio Tomita
    • 1
  • Takeo Kosaka
    • 1
  • Ichirou Kita
    • 1
  • Shigeki Takashima
    • 1
  • Hisao Matsunou
    • 2
  1. 1.Second Department of SurgeryKanazawa Medical UniversityIshikawaJapan
  2. 2.Second Department of PathologyKanazawa Medical UniversityIshikawaJapan

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