Single oral dose of cisapride accelerates gastric antral emptying in healthy humans: An ultrasonographic study
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An ultrasonographic study of ten healthy volunteers was carried out to evaluate the effect of cisapride on gastric antral emptying. More than 1 week after the measurement of the baseline emptying rate, cisapride was given at a single oral dose of 5 mg 30 minutes before intake of a balanced liquid test meal (5 ml/kg body weight). To determine the time to half emptying (T1/2), an exponential curve was extrapolated for the elimination phase of the gastroantral sagittal cross-sectional area plotted against time. The T1/2 was reduced by 18.5% after cisapride, from 62.6±4.3 to 51.0±4.4 min (P=0.0284). We conclude that a single oral dose of 5mg of cisapride significantly accelerates the gastric antral emptying rate in healthy humans.
Key wordscisapride exponential curve gastric antral emptying ultrasonography
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- 3.Tympner F. Ultrasound study of the effect of cisapride on gastric emptying time. Digestion 1986;34:150.Google Scholar
- 12.Akkermans JMA, Jacobs F, Smout AJPM, et al. Radionuclide measurement of normal and disturbed gastric mobility Scand J Gastroenterol [Suppl] 1984;96:19–26.Google Scholar
- 15.Van Wyk M, Sommers DK, Moncrieff J. Influence of cisapride, metoclopramide and loperamide on gastric emptying of normal volunteers as measured by means of the area under the curve of the cumulative fraction absorbed-time profiles of paracetamol. Methods Find Exp Clin Pharmacol 1992;14:379–382.PubMedGoogle Scholar
- 27.Reyntjens A, Verlinden M, Aerts T. Development and clinical use of the new gastrointestinal prokinetic drug cisapride (R 51619). Drug Devel Res 1986;8:251–265.Google Scholar