Journal of Gastroenterology

, Volume 31, Issue 3, pp 323–328 | Cite as

Single oral dose of cisapride accelerates gastric antral emptying in healthy humans: An ultrasonographic study

  • Torahiko Takeda
  • Hiroyuki Konomi
  • Gen Naritomi
  • Junichi Yoshida
  • Hiroaki Matsunaga
  • Kouhei Akazawa
  • Masao Tanaka
Alimentary Tract

Abstract

An ultrasonographic study of ten healthy volunteers was carried out to evaluate the effect of cisapride on gastric antral emptying. More than 1 week after the measurement of the baseline emptying rate, cisapride was given at a single oral dose of 5 mg 30 minutes before intake of a balanced liquid test meal (5 ml/kg body weight). To determine the time to half emptying (T1/2), an exponential curve was extrapolated for the elimination phase of the gastroantral sagittal cross-sectional area plotted against time. The T1/2 was reduced by 18.5% after cisapride, from 62.6±4.3 to 51.0±4.4 min (P=0.0284). We conclude that a single oral dose of 5mg of cisapride significantly accelerates the gastric antral emptying rate in healthy humans.

Key words

cisapride exponential curve gastric antral emptying ultrasonography 

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Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • Torahiko Takeda
    • 1
  • Hiroyuki Konomi
    • 1
  • Gen Naritomi
    • 1
  • Junichi Yoshida
    • 1
  • Hiroaki Matsunaga
    • 1
  • Kouhei Akazawa
    • 2
  • Masao Tanaka
    • 1
  1. 1.First Department of SurgeryKyushu University Faculty of MedicineFukuokaJapan
  2. 2.Department of Medical InformaticsKyushu University Faculty of MedicineFukuokaJapan

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