Summary
Adrenocortical mitochondrial cholesterol side chain cleavage reactions are regulated by the influence of pituitary ACTH. The mechanism of the stimulation involves adenyl cyclase, cAMP-dependent protein kinase, cholesterol esterase, and ribosomal labile protein synthesis. Through these reactions the stimulus reaches the mitochondrial side chain cleavage enzyme system. In this review article, the current implications on the stimulus transfer from the plasma membrane to the mitochondrial inner membrane are summarized. In particular the availability of cholesterol to P-450scc was discussed in terms of the distribution of cholesterol molecules in the membranes.
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References
Hoffman, K., 1962. Ann. Rev. Biochem. 31: 213–246.
Stone, D. & Hechter, O., 1954. Arch. Biochem. Biophys. 51: 457–469.
Constantopoulos, G. & Tchen, T. T., 1961. Biochem. Biophys. res. Commun. 4: 460–463.
Garren, L. D., Ney, R. L. & Davis, W. W., 1965. Proc. Natl. Acad. Sci., U.S. 53: 1443–1450.
Sayers, G., Beall, R. J. & Seelig, S., 1972. Science 175: 1131–1133.
Suzuki, K. & Kimura, T., 1965. Biochem. Biophys. Res. Commun. 19: 340–345.
Kimura, T. & Suzuki, K., 1967. J. Biol. Chem. 242: 485–491.
Nakamura, Y., Otsuka, H. & Tamaoki, B., 1966. Biochim. Biophys. Acta 122: 34–42.
Omura, T., Sato, R., Cooper, D. Y., Rosenthal, O. & Estabrook, R. W., 1965. Fed. Proc. 24: 1181–1189.
Chu, J. W. & Kimura, T., 1973. J. Biol. Chem. 248: 2089–2094.
Chu, J. W. & Kimura, T., 1973. J. Biol. Chem. 248: 5183–5187.
Iyanagi, T. & Mason, H. S., 1973. Biochemistry 12: 2297–2308.
Kimura, T., Suzuki, K., Padmanabhan, T., Samejima, T., Tarutani, O. & Ui, N., 1969. Biochemistry 8: 4027–4031.
Watari, H. & Kimura, T., 1966. Biochem. Biophys. Res. Commun. 24: 106–122.
Kimura, T., Tasaki, A. & Watari, H., 1970. J. Biol. Chem. 245: 4450–4452.
Katagiri, M., Takemori, S., Itagaki, E., Suhara, K., Gomi, T. & Sato, H., 1976. In: Iron and copper proteins (Yasunobu, K. T., Mower, H. F. & Hayaishi, O., Eds.), pp. 281–289, Plenum Press, New York.
Wang, H. P. & Kimura, T., 1976. J. Biol. Chem. 251: 6068–6074.
Huang, J. J. & Kimura, T., 1970. Biochem. Biophys. Res. Commun. 41: 737–740.
Gunsalus, I. C., 1976. In: The Structural Basis of Membrane Function (Hatefi, Y. & Djavadi-Ohaniance, L., Eds.), p. 377–387, Academic Press, New York.
White, R. E. & Coon, M. J., 1980. Ann. Rev. Biochem. 49: 315–356.
Sato, R. & Omura, T., 1978. Cytochrome P450, Kodansha and Academic Press, Tokyo and New York.
Mitani, F., 1979. Mol. Cell. Biochem. 24: 21–43.
Simpson, E. R., 1979. Mol. Cell. Endocrinology 13: 213–227.
Haynes, R. C., Jr., 1958. J. Biol. Chem. 233: 1220–1222.
Haynes, R. C., Jr., Koritz, S. B. & Peron, F. G., 1959. J. Biol. Chem. 234: 1421–1423.
Grahame-Smith, D. G., Butcher, R. W., Ney, R. L. & Sutherland, E. W., 1967. J. Biol. Chem. 242: 5535–5541.
Ide, M., Tanaka, A., Nakamura, M. & Okabayashi, T., 1972. Arch. Biochem. Biophys. 149: 189–196.
Rae, P. A., Tsao, J. & Schimmer, B. P., 1979. Can. J. Biochem. 57: 509–516.
Saez, J. M., Morera, A. M., Dazord, A. & Bataille, P., 1974. J. Steroid Biochem. 5: 925–933.
Dazord, A., Saez, J. M., Morera, A. M. & Bataille, P., 1975. J. Biol. Chem. 250: 1683–1689.
Schimmer, B. P., Ueda, K. & Sato, G. H., 1968. Biochem. Biophys. Res. Commun. 32: 806–810.
Gordon, P., Carpentier, J. L., Freychet, P., LeCam, A. & Orci, L., 1978. Science, 200: 782–785.
Ascoli, M. & Puett, D., 1978. J. Biol. Chem. 253: 4892–4899.
Carpenter, G. & Cohen, S., 1976. J. Cell. Biol. 71: 159–171.
Goldstein, J. L. & Brown, M. S., 1977. Ann. Rev. Biochem. 46: 897–930.
Dorland, R. B., Middlebrook, J. L. & Leppla, S. H., 1979. J. Biol. Chem. 254: 11337–11342.
Schlessinger, J., 1980. TIBS 5: 210–214.
Palfreyman, J. W. & Schulster, D., 1975. Biochim. Biophys. Acta, 404: 221–230.
Carpenter, G., King, L. & Cohen, S., 1979. J. Biol. Chem. 254: 4884–4891.
Das, M., 1980. Proc. Natl. Acad. Sci., U. S. 77: 112–116.
Hirata, F., Strittmatter, W. J. & Axelrod, F., 1979. Proc. Natl. Acad. Sci. U. S. 76: 368–372.
Schrey, M. P. & Rubin, R. P., 1979. J. Biol. Chem. 254: 11234–11241.
Graff, G., Stephenson, J. H., Glass, D. B., Haddox, M. K. & Goldberg, N. D., 1978. J. Biol. Chem. 253: 7662–7676.
Rubin, C. S. & Rosen, O. M., 1975. Ann. Rev. Biochem. 44: 831–887.
Brostrom, C. O., Corbin, J. D., King, C. A. & Krebs, E. G., 1971. Proc. Natl. Acad. Sci., U. S. 68: 2444–2447.
Gorbin, J. D., Sugden, D. H., West, L., Flockhart, D. A., Lincoln, T. M. & McCarthy, D., 1978. J. Biol. Chem. 253: 3997–4003.
Boyd, G. S. & Trzeciak, W. H., 1973. Ann. N. Y., Acad. Sci. 212: 361–377.
Trzeciak, W. H. & Boyd, G. S., 1974. Eur. J. Biochem. 46: 201–207.
Huttunen, J. K., Steinberg, D., and Mayer, S. E., 1970. Proc. Natl. Acad. Sci., U. S. 67: 290–295.
Simpson, E. R. & Mason, J. I., 1976. In: International encyclopaedia of Pharmacology and Therapeutics, B (Gill, G. N., Ed.), vol. 2, pp 339–369, Pergamon Press, Oxford.
Wettenhall, R. E. H., & Slobbe, A., 1976. Exp. Cell. Res. 99: 189–193.
Schlegel, W., 1976. FEBS Letters 69: 67–69.
Smith, C. J., Wejksnora, P. J., Warren, J. R., Rubin, C. & Rosen, O. M., 1979. Proc. Natl. Acad. Sci., U. S. 76: 2725–2729.
Koroscil, T. M. & Gallant, S., 1980. J. Biol. Chem. 255, 6276–6283.
Sharma, R. K., Ahmed N. K. & Shanker, G., (1976). Eur. J. Biochem. 70: 427–433.
Perchellet, J. P. & Sharma, R. K., 1979. Science 203: 1259–1261.
Rolland, P. H. & Chambez, E. M., 1977. Mol. Cell. Endocrinol. 7: 325–333.
Mason, J. I., Arthur, J. R. & Boyd, G. S., 1978. Mol. Cell. Endocrinol. 10: 209–223.
Battista, J. R. & Honn, K. V., 1980. Biochem. Biophys. Res. Commun. 93: 1104–1109.
Stroeve, P. & Miller, I., 1975. Biochim. Biophys. Acta 401: 157–167.
Kirby, C. J. & Green, C., 1977. Biochem. J. 168: 575–577.
Smith, R. J. M. & Green, C., 1974. FEBS Letters 42: 108–111.
Bloj, B. & Zilversmit, D. B., 1977. Biochemistry 16: 3943–3948.
Poznansky, M. J. & Lange, Y., 1978. Biochim. Biophys. Acta 506: 256–264.
Patzer, E. J., Shaw, J. M., Moore, N. F., Thompson, T. E. & Wagner, R. R., 1978. Biochemistry 17: 4192–4200.
Rubenstein, J. L., Owicki, J. C. & McConnell, H. M., 1980. Biochemistry 19: 569–573.
Bicknell-Brown, E. & Brown, K. G., 1980. Biochem. Biophys. Res. Commun. 94: 638–645.
Bush, S. F., Levin, H. & Levin, I. W., 1980. Chem. Phys. Lipids 27: 101–111.
Demel, R. A. & DeKruijff, B., 1976. Biochim. Biophys. Acta 457: 109–132.
Lala, A. K., Butteke, T. M. & Bloch, K., 1980. J. Biol. Chem. 254: 10582–10585.
Dahl, C. E., Dahl, J. S. & Bloch, K., 1980. Biochem. Biophys. Res. Commun. 92: 221–228.
Backer, J. M. & Dawidowicz, E. A., 1979. Biochim. Biophys. Acta 551: 260–270.
Nakagawa, Y., Utsumi, H., Inoue, K. & Nojima, S., 1979. J. Biochem. 86: 783–788.
Nakagawa, Y., Nojima, S. & Inoue, K., 1980. J. Biochem. 87: 497–502.
Poznansky, M. J. & Czekanski, S., 1979. Biochem. J. 177: 989–991.
Kimura, T., 1969. Endocrinology 85: 492–499.
Pfeiffer, D. R., Chu, J. W., Kuo, T. H., Shan, S. W., Kimura, T. & Tchen, T. T., 1972. Biochem. Biophys. Res. Commun. 48: 486–490.
Purvis, J. L., Canick, J. A., Mason, J. I., Estabrook, R. W., & McCarthy, J. L., 1973. Ann. N. Y. Acad. Sci. 212: 319–343.
McDonald, G. G., Vanderkooi, J. M. & Oberholtzer, J. C., 1979. Arch. Biochem. Biophys. 196: 281–283.
Lackowicz, J. & Weber, G., 1973. Biochemistry, 12: 4171–4179.
Kimura, T., 1966. Seikagaku 38: 209–223.
Klimek, J., Boguslawski, W. & Zelewski, L., 1979. Biochim. Biophys. Acta 587: 362–372.
Kimura, T. & Tchen, T. T., 1968. Gunma Symposia on Endocrinology 5: 181–184.
Yago, N. & Ichii, S., 1969. J. Biochem. 65: 215–224.
Satre, M., Vignais, P. V. & Idelman, S., 1969. FEBS Letters 5: 135–140.
Satre, M. & Vignais, P. V., Biochemistry 13: 2201–2209.
Kimura, T., Wang, H. P., Chu, J. W., Churchill, P. F. & Parcells, J., 1976. In: The Structural Basis of Membrane Function (Hatefi, Y. & Djavadi-Ohniance, L., Eds.), pp 447–461, Academic Press, New York.
Oldham, S. B., Bell, J. J. & Harding, B. W., 1968. Biochim. Biophys. Acta 92: 415–417.
Cammer, W. & Estabrook, R. W., 1967. Arch. Biochem. Biophys. 122: 735–747.
Churchill, P. F., deAlvare, L. R. & Kimura, T., 1978. J. Biol. Chem. 253: 4924–4929.
Churchill, P. F. & Kimura, T., 1979. J. Biol. Chem. 254: 10443–10448.
Rydstom, J., Gustafsson, J. Å., Ingelman-Sundberg, M., Montelius, J. & Ernster, L., 1976. Biochem. Biophys. Res. Commun. 73: 555–561.
Blum, H., Leigh, J. S., Salerno, J. C. & Ohnishi, T., 1978. FEBS Letters 187: 153–157.
Colbeau, A., Nachbauer, J. & Vignais, P. M., 1971. Biochim. Biophys. Acta 249: 462–492.
Yago, N., Kobayashi, S., Sekiyama, S., Kurokawa, H., Iwai, Y., Suzuki, I. & Ichii, S., 1970. J. Biochem. 68: 775–783.
DeKruijff, B., Cullis, P. R. & Radda, G. K., 1975. Biochim. Biophys. Acta 406: 6–20.
DeKruijff, B., Cullis, P. R. & Radda, G. K., 1976. Biochim. Biophys. Acta 436: 729–740.
Lehninger, A., 1976. In: Biochemistry, 2nd Ed., pp. 370–371, Worth Publishers, New York.
Poo, M. & Cone, R. A., 1974. Nature 247: 438–441.
Schlessinger, J., Koppel, D. E., Axelrod, D., Jacobson, K., Webb, W. W. & Elson, E. L., 1976. Proc. Natl. Acad. Sci., U. S. 73: 2409–2413.
Peters, R., Peters, J., Tews, K. H. & Bähr, W., 1974. Biochim. Biophys. Acta 367: 282–294.
Kimura, T., Chu, J. W. & Parcells, J., 1976. In: Flavis and Flavoproteins (Singer, T. P., Ed.), pp 637–646, Elsevier, Amsterdam.
Hiwatashi, A., Ichikawa, Y., Maruyama, N., Yamano, T. & Aki, K., 1976. Biochemistry 15: 3082–3090.
Hiwatashi, A., Ichikawa, Y., Yamano, T. & Maruyama, N., 1976. Biochemistry 15: 3091–3097.
Miura, R., Sugiyama, T. & Yamano, T., 1979. J. Biochem. 85: 1107–1113.
Lambeth, J. D. & Kamin, H., 1976. J. Biol. Chem. 251: 4299–4306.
Lambeth, J. D., McCaslin, D. R. & Kamin, H., 1976. J. Biol. Chem. 251: 7545–7550.
Lambeth, J. D. & Kamin, H., 1977. J. Biol. Chem. 252: 2908–2917.
Taniguchi, T. & Kimura, T., 1975. Biochemistry 14: 5573–5578.
Taniguchi, T. & Kimura, T., 1976. Biochemistry 15: 2849–2853.
Lambeth, D. J. & Kamin, H., 1979. J. Biol. Chem. 254: 2766–2774.
Seybert, D. W., Lambeth, J. D. & Kamin, H., 1978. J. Biol. Chem. 253: 8355–8358.
Hanukoglu, I. & Jefcoate, C. R., 1980. J. Biol. Chem. 255: 3057–3061.
Katagiri, M., Takikawa, O., Sato, H. & Suhara, K., 1977. Biochem. Biophys. Res. Commun. 77: 804–809.
Kido, T., Arakawa, M. & Kimura, T., 1979. J. Biol. Chem. 254: 8377–8385.
Kido, T. & Kimura, T., 1979. J. Biol. Chem. 254: 11806–11815.
Nakajin, S., Ishii, Y., Shinoda, M. & Shikita, M., 1979. Biochem. Biophys. Res. Commun. 87: 524–531.
Takikawa, O., Gomi, T., Suhara, K., Itagaki, E., Takemori, S. & Katagiri, M., 1978. Arch. Biochem. Biophys. 190: 300–306.
Kimura, T., Parcells, J. H. & Wang, H. P., 1978. Methods in Enzymol. 52: 132–142.
Ohashi, M. & Omura, T., 1978. J. Biochem. 83: 249–260.
Lambeth, D. J., Seybert, D. W. & Kamin, H., 1979. J. Biol. Chem. 254: 7255–7264.
Lambeth, D. J., Seybert, D. W. & Kamin, H., 1980. J. Biol. Chem. 255: 4667–4672.
Lambeth, D. J., Seybert, D. W. & Kamin, H., 1980. J. Biol. Chem. 255: 138–143.
Haberland, M. E. & Reynolds, J. A., 1973. Proc. Natl. Acad. Sci., U. S. 70: 2313–2316.
Kido, T., Yamakura, F. & Kimura, T., 1980. In: Symposium of Biochemistry, Biophys. and Regulation of Cytochrome P450 (Gustafsson, J.-Å., Ed.), Elsevier, pp. 519–522.
Mukai, K., Kimura, T., Helbert, J. & Kevan, L., 1973. Biochim. Biophys. Acta 295: 49–56.
Ito, A. & Sato, R., 1968. J. Biol. Chem. 243: 4922–4923.
Orme-Johnson, N. R., Light, D. R., White-Stevens, R. W. & Orme-Johnson, W. H., 1979. J. Biol. Chem. 254: 2103–2111.
Brownie, A. C., Alfano, J., Jefcoate, C. R., Orme-Johnson, W. H. & Simpson, E. R., 1973. Ann. N. Y. Acad. Sci. 212: 344–360.
Brownie, A. C., Simpson, E. R., Jefcoate, C. R., Boyd, G. S., Orme-Johnson, W. H. & Beinert, H., 1972. Biochem. Biophys. Res. Commun. 46: 483–490.
Williams-Smith, D. L., Simpson, E. R., Barlow, S. M. & Morrison, P. J., 1976. Biochim. Biophys. Acta 499: 72–83.
Jefcoate, C. R., Orme-Johnson, W. H. & Beinert, H., 1976. J. Biol. Chem. 251: 3706–3715.
Paul, D. P., Gallant, S., Orme-Johnson, N. R., Orme-Johnson, W. H. & Brownie, A. C., 1976. J. Biol. Chem. 251: 7120–7126.
Simpson, E. R., McCarthy, J. L. & Peterson, J. A., 1978. J. Biol. Chem. 253: 3135–3139.
Kuo, T. H. & Tchen, T. T., 1973. J. Biol. Chem. 248: 6679–6683.
Mahaffee, D., Reitz, R. C. & Ney, R. L., 1974. J. Biol. Chem. 247: 1462–1472.
Arthur, J. R., Mason, J. I. & Boyd, G. S., 1976. FEBS Letters 66: 206–209.
Jefcoate, C. R., Simpson, E. R. & Boyd, G. S., 1974. Eur. J. Biochem. 42: 539–551.
unpublished data by Cheng, B. L. & Kimura, T.
Mason, J. I., Arthur, J. R. & Boyd, G. S., 1978. Biochem. J. 173: 1045–1051.
Farese, R. V. & Prudente, W. J., 1978. Biochim. Biophys. Acta 544: 77–84.
Farese, R. V. & Sabir, M. A., 1979. Biochim. Biophys. Acta 575: 299–304.
Farese, R. V., Sabir, M. A. & Vandor, S. L., 1979. J. Biol. Chem. 254: 6842–6844.
Farese, R. V., Prudente, W. J. & Chuang, L. T., 1980. Biochem. J. 186: 145–152.
Farese, R. V., Sabir, M. A., Vandor, S. L. & Larson, R. E., 1980. J. Biol. Chem. 255: 5728–5734.
Farese, R. V., Sabir, M. A. & Larson, R. E., 1980. J. Biol. Chem. 255: 7232–7237.
Wang, H. P., Pfeiffer, D. R., Kimura, T. & Tchen, T. T., 1974. Biochem. Biophys. Res. Commun. 57: 93–99.
Wang, H. P. & Kimura, T., 1978. Biochim. Biophys. Acta 542: 115–117.
Ichii, S., Ikeda, A., Ohta, A. & Izawa, A., 1972. J. Biochem. 71: 615–623.
Thomas, J. O. & Edelstein, S. J., 1972. J. Biol. Chem. 247: 7870–7874.
Hochman, J., Garish, M., Inbar, D. & Givol, D., 1976. Biochemistry 15: 2706–2710.
Chan, W. W-C., 1978. Eur. J. Biochem. 90: 271–281.
Hoagland, V. D., Jr. & Teller, D. C., 1969. Biochemistry 8: 594–602.
Hathaway, G. M. & Grawford, I. P., 1970. Biochemistry 9: 1801–1808.
Gilleland, M. J. & Bender, M. L., 1976. J. Biol. Chem. 251: 498–502.
Tuzuki, J. & Kiger, J. A., Jr., 1978. Biochemistry 17: 2961–2970.
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Kimura, T. ACTH stimulation on cholesterol side chain cleavage activity of adrenocortical mitochondria. Mol Cell Biochem 36, 105–122 (1981). https://doi.org/10.1007/BF02354909
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DOI: https://doi.org/10.1007/BF02354909