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Acetylcholinesterase from rat red cells and cholinesterase ofPseudomonas aeruginosa: Different types of inhibition by atropine

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Summary

The inhibition by atropine of cholinesterase from Pseudomonas aeruginosa has been studied in parallel with the membrane bound acetylcholinesterase from rat red cells.

Acetylcholinesterase of rat red cells, like other animal cholinesterases, was competitively inhibited while the cholinesterase fromPseudomonas aeruginosa was partially non competitively inhibited by atropine.

These results clearly indicated a different behavior of cholinesterase fromPseudomonas aeruginosa in comparison with the enzyme ofPseudomonas fluorescens and other animal cholinesterases.

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Authors and Affiliations

  1. Quimica Biológica, Departamento de Biología Molecular, Facultad de Ciencias Exactas, Físico-Quimicas y Naturales, Universidad Nacional de Río Cuarto, 5800, Río Cuarto, Argentina

    Carlos E. Domenech, Mónica N. Garrido, Estela E. Machado de Domenech & Teresita A. Lisa

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  1. Carlos E. Domenech
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  2. Mónica N. Garrido
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  3. Estela E. Machado de Domenech
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  4. Teresita A. Lisa
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Domenech, C.E., Garrido, M.N., Machado de Domenech, E.E. et al. Acetylcholinesterase from rat red cells and cholinesterase ofPseudomonas aeruginosa: Different types of inhibition by atropine. Mol Cell Biochem 34, 95–99 (1981). https://doi.org/10.1007/BF02354863

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  • DOI: https://doi.org/10.1007/BF02354863

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