A semicompartmental modeling approach for pharmacodynamic data assessment

  • Kenneth G. Kowalski
  • Aziz Karim


A new method is proposed for modeling the temporal aspects of the pharmacodynamic-pharmacokinetic relationship of drugs. A semicompartmental solution to the effect-site link model of Sheiner et al. (1) formed the basis for this new approach. This semicompartmental solution does not require the specification of a compartmental model for the pharmacokinetic response and may offer an advantage when model misspecification is present in using standard compartmental models. A Monte Carlo simulation study was conducted to evaluate the performance of the semicompartmental modeling approach. This method is easily implemented in standard nonlinear regression packages.

Key words

effect-site link model semicompartmental model model misspecification pharmacokinetics pharmacodynamics nonlinear regression 


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Copyright information

© Plenum Publishing Corporation 1995

Authors and Affiliations

  • Kenneth G. Kowalski
    • 1
  • Aziz Karim
    • 2
  1. 1.Department of Statistics and Clinical Data Management, Searle Research and DevelopmentSkokie
  2. 2.Department of Clinical Pharmacokinetics and Bioavailability, Searle Research and DevelopmentSkokie

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