Correlation between radiographic mode of bone destruction and effect of combined radiotherapy for squamous cell carcinoma of the lower gingiva
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Sixty-nine patients with squamous cell carcinoma of the lower gingiva were treated by external radiotherapy combined with Bleomycin (BLM) or Peplomycin (PEP) at the Department of Radiology, Osaka University Hospital from 1974 to 1986.
The radiographic patterns of mandibular bone destruction were grouped into 3 main types as: pressure, permeated and moth-eaten. These radiographic modes of bone destruction were reviewed in relation to the effects of the combined radiotherapy.
The external irradiation of a small dose (30Gy) with simultaneous use of BLM/PEP provided good local control without surgery. The pressure and permeated types of bone destruction showed a better radioresponse than the moth-eaten type.
Key WordsCarcinoma of the lower gingiva Bone destruction Combined radiotherapy
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