Journal of Molecular Evolution

, Volume 43, Issue 1, pp 1–3 | Cite as

A fitness principle for pre-Darwinian evolution based on selection of the least action path

  • Brian K. Davis


Action Path Fitness Principle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Davis BK (1978a) Rate of polymer formation and entropy production d uring competitive replication. J Mol Evol 10:325–338CrossRefGoogle Scholar
  2. Davis BK (1978b) Change in polymerization rate and entropy production during competitive replication. In: Agris Pet al. (eds) Biomolecular structure and function. Academic Press, New York, pp 607–610Google Scholar
  3. Davis BK (1991a) Variation in polymer fitness at elevated mutation rates. Bull Math Biol 53:751–768CrossRefGoogle Scholar
  4. Davis BK (1991b) Kinetics of rapid RNA evolution in vitro. J Mol Evol 33:343–356CrossRefGoogle Scholar
  5. Davis BK (1994) Complexity acquisition during prebiotic evolution. Origins of Life 24:205–206Google Scholar
  6. Eigen M, Biebricher CK (1988) Sequence space and quasispecies distribution. In: Domingo Eet al. (eds) RNA genetics, vol. 3. CRC Press, Boca Raton, pp 211–245Google Scholar
  7. Fakhrai H, Inoue T, Orgel LE (1984) Temperature-dependence of the template-directed synthesis of oligonucleotides. Tetrahedron 40: 39–45CrossRefPubMedGoogle Scholar
  8. Fisher RA (1930) The genetical theory of natural selection, 2nd ed. 1958, Dover, New YorkGoogle Scholar
  9. Kanavarioti A, Bernasconi CF (1990) Computer simulation in template-directed oligoguanylate synthesis. J Mol Evol 31:470–477PubMedGoogle Scholar
  10. Kimura M (1958) On the change of population fitness by natural selection. Heredity 12:145–167Google Scholar
  11. Kramer FR, Mills DR, Cole PE, Nishara T, Spiegelman S (1974) Evolution in vitro: sequence and phenotype of the mutant RNA resistant to ethidium bromide. J Mot Biel 89:719–736Google Scholar
  12. Pontryagin LS, Boltyanskii VG, Gamkrelidze RV, Mischenko EF (1962) The mathematical theory of optimal processes. Wiley, New YorkGoogle Scholar
  13. Shahshahani S (1979) A new mathematical framework for the study of linkage and selection. Mem Am Math Soc 17:1–34Google Scholar
  14. von Kiedrowski G, Wlotzka B, Helbing J, Matzen M, Jordan S (1991) Parabolic growth of a self-replicating hexadeoxynucleotide bearing a 3′,5′-phosphoamidate linkage. Ang Chem Intl Ed Engl 30:423–426Google Scholar

Copyright information

© Springer-Verlag New York Inc 1996

Authors and Affiliations

  • Brian K. Davis
    • 1
  1. 1.Research Foundation of Southern California, Inc.La JollaUSA

Personalised recommendations